Central corneal thickness and thickness of the lamina cribrosa in human eyes
Central corneal thickness and thickness of the lamina cribrosa in human eyes
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DOI：
10.1167/iovs.04-0851
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发表时间：
2005-04-01
影响因子：
4.4
通讯作者：
Holbach, L
中科院分区：
文献类型：
--
作者：
Jonas, JB;Holbach, L
目的.由于中央角膜厚度可能对青光眼视神经损伤的数量和进展速度产生相反的影响，并且由于筛板厚度可能在青光眼易感性中起重要作用，因此本研究的目的是评估中央角膜厚度是否与筛板厚度相关。组织形态计量学研究包括111名白色受试者的111只摘除的非青光眼眼。在通过瞳孔和中央视盘区域的前后组织切片上，测量角膜、筛板和视乳头周围巩膜的厚度以及眼内间隙和脑脊液间隙之间的最短距离。轴向长度范围为20至32 mm。平均中央角膜厚度（平均值+/- SD：616.6 +/- 108.3 μ m）和平均中央筛板厚度（378.1 +/- 117.8 μ m）在统计学上相互独立（P = 0.15;相关系数，r = 0.14）。同样，视盘边缘的筛板厚度与中央角膜厚度（P = 0.51; r = 0.06）和周边角膜厚度（P = 0.34; r = 0.09）在统计学上无关。同时，视乳头周围巩膜厚度（P = 0.84）和板前间隙至脑脊液间隙的最短距离（P = 0.10）与中央角膜厚度无关。在非青光眼的人类眼球中，中央角膜厚度可能与筛板厚度、视乳头周围巩膜厚度以及眼内空间与脑脊液空间之间的最短距离无显著相关性。组织学伪影和切片方法可以部分解释缺乏相关性。研究结果可能表明，中央角膜厚度和青光眼易感性之间的假设关系，不能解释角膜厚度和视神经乳头的组织形态计量学之间的解剖学对应关系。
PURPOSE. Since central corneal thickness may inversely influence the amount and rate of progression of glaucomatous optic nerve damage and because lamina cribrosa thickness may be of importance in susceptibility to glaucoma, it was the purpose of the present study to evaluate whether central corneal thickness is related to lamina cribrosa thickness.METHODS. The histomorphometric study included 111 enucleated nonglaucomatous eyes of 111 white subjects. On anterior - posterior histologic sections through the pupil and the central optic disc region, the thickness of the cornea, lamina cribrosa, and peripapillary sclera and the shortest distance between the intraocular space and the cerebrospinal fluid space were measured. Axial length ranged between 20 and 32 mm.RESULTS. Mean central corneal thickness ( mean +/- SD: 616.6 +/- 108.3 mu m) and mean central lamina cribrosa thickness ( 378.1 +/- 117.8 mu m) were statistically independent of each other ( P = 0.15; correlation coefficient, r = 0.14). In a similar manner, lamina cribrosa thickness at the optic disc border was statistically independent of central corneal thickness ( P = 0.51; r = 0.06) and peripheral corneal thickness ( P = 0.34; r = 0.09). In a parallel way, peripapillary scleral thickness ( P = 0.84) and the shortest distance between the prelaminar space and cerebrospinal fluid space ( P = 0.10) were statistically independent of central corneal thickness.CONCLUSIONS. In nonglaucomatous human globes, central corneal thickness may not correlate significantly with lamina cribrosa thickness, peripapillary scleral thickness, and shortest distance between intraocular space and cerebrospinal fluid space. Histologic artifact and sectioning methods could partially account for the lack of an association. The study results may suggest clinically that an assumed relationship between central corneal thickness and susceptibility to glaucoma cannot be explained by an anatomic correspondence between corneal thickness and histomorphometry of the optic nerve head.