Ultrasonic standing wave preparation of a liquid cell for glucose measurements in urine by midinfrared spectroscopy and potential application to smart toilets
Ultrasonic standing wave preparation of a liquid cell for glucose measurements in urine by midinfrared spectroscopy and potential application to smart toilets
复制标题
超声波驻波制备液体细胞，用于通过中红外光谱测量尿液中的葡萄糖以及在智能马桶中的潜在应用
DOI：
10.1117/1.jbo.23.5.050503
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发表时间：
2018
影响因子：
3.5
通讯作者：
Naoyuki Yamamoto Natsumi Kawashima Tomoya Kitazaki Keita Mori Hanyue Kang Akira Nishiyama Kenji Wada Ichiro Ishimaru
中科院分区：
文献类型：
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作者：
Kawashima Natsumi;Kitazaki Tomoya;Nogo Kosuke;Nishiyama Akira;Wada Kenji;Ishimaru Ichiro;Tomoya Kitazaki; Natsumi Kawashima; Naoyuki Yamamoto; Hiroyuki Nomura; Hanyue Kang; Akira Nishiyama; Kenji Wada; Ichiro Ishimaru;Naoyuki Yamamoto Natsumi Kawashima Tomoya Kitazaki Keita Mori Hanyue Kang Akira Nishiyama Kenji Wada Ichiro Ishimaru
智能马桶可以用来监测日常生活中尿液的不同成分，以便及早发现与生活方式相关的疾病，并迅速提供治疗。对于尿液等生物样品的中红外光谱分析，由于水对中红外光的强烈吸收，需要像液胞一样的薄膜样品。传统的液体电池或固定电池是基于液膜法和溶液技术制备的，但这些都是不定量的，安装和清洗困难。我们在样品中产生了一个超声波驻波反射面，并制作了一个超声波液晶盒。在该池中，与传统方法一样，光路长度的厚度是可调整的。通过改变超声波的频率，可以在任意深度产生反射面，检测到内反射光。我们可以利用超声驻波产生的密度差来产生折射率边界。光学相干层析成像证实了样品中反射面的产生。利用该方法和中红外光谱对不同浓度葡萄糖的正常尿样进行了鉴别，获得了较高的相关系数。
Smart toilets could be used to monitor different components of urine in daily life for early detection of lifestyle-related diseases and prompt provision of treatment. For analysis of biological samples such as urine by midinfrared spectroscopy, thin-film samples like liquid cells are needed because of the strong absorption of midinfrared light by water. Conventional liquid cells or fixed cells are prepared based on the liquid membrane method and solution technique, but these are not quantitative and are difficult to set up and clean. We generated an ultrasonic standing wave reflection plane in a sample and produced an ultrasonic liquid cell. In this cell, the thickness of the optical path length was adjustable, as in the conventional method. The reflection plane could be generated at an arbitrary depth and internal reflected light could be detected by changing the frequency of the ultrasonic wave. We could generate refractive index boundaries using the density difference created by the ultrasonic standing wave. Creation of the reflection plane in the sample was confirmed by optical coherence tomography. Using the proposed method and midinfrared spectroscopy, we discriminated between normal urine samples spiked with glucose at different concentrations and obtained a high correlation coefficient.