Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.
Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.
复制标题
朗格汉斯剂量测定的整个器官和胰岛，用于计算放射性标记的毒蜥外泌肽成像产生的吸收剂量。
DOI：
10.1038/srep39800
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发表时间：
2017
影响因子：
4.6
通讯作者：
Gotthardt,Martin
中科院分区：
文献类型：
--
作者：
vanderKroon,Inge;Woliner-vanderWeg,Wietske;Brom,Maarten;Joosten,Lieke;Frielink,Cathelijne;Konijnenberg,MarkW;Visser,EricP;Gotthardt,Martin
放射性标记的exendin用于非侵入性定量测定活体朗格汉辛胰岛中的β细胞。放射性标记的exendin在胰岛中的高度积累引起了人们对这些胰岛可能受到辐射损伤的担忧。在这项工作中，通过结合整体器官剂量学和小尺度胰岛剂量学，计算了由Exendin成像产生的胰岛吸收剂量。我们的模型包含了放射性标记exendin高度积累的组织：肾脏、胰腺和胰岛。作为模型的输入，使用了来自临床研究(放射性标记的exendin在人体中的分布)和来自生物喂养糖尿病倾向(BBDP)大鼠的临床前研究(胰岛与外分泌摄取比率，β细胞质量)的数据。我们模拟了性别、胰岛大小、β细胞质量和肾脏放射性药物摄取不同的患者的111 In-Exendin和68Ga-Exendin吸收剂量。在所有模拟病例中，胰岛的吸收剂量都很小，68Ga的最大吸收剂量为1.38 mGY，111In的最大吸收剂量为66.0 mGy.胰岛吸收剂量的两个主要来源是肾脏(33-61%)和胰岛自身剂量(7.5-57%)。总而言之，所有胰岛吸收的剂量都很低(<；70 mGy)，所以即使重复成像也不会增加患糖尿病的风险。
Radiolabeled exendin is used for non-invasive quantification of beta cells in the islets of Langerhansin vivo. High accumulation of radiolabeled exendin in the islets raised concerns about possible radiation-induced damage to these islets in man. In this work, islet absorbed doses resulting from exendin-imaging were calculated by combining whole organ dosimetry with small scale dosimetry for the islets. Our model contains the tissues with high accumulation of radiolabeled exendin: kidneys, pancreas and islets. As input for the model, data from a clinical study (radiolabeled exendin distribution in the human body) and from a preclinical study with Biobreeding Diabetes Prone (BBDP) rats (islet-to-exocrine uptake ratio, beta cell mass) were used. We simulated111In-exendin and68Ga-exendin absorbed doses in patients with differences in gender, islet size, beta cell mass and radiopharmaceutical uptake in the kidneys. In all simulated cases the islet absorbed dose was small, maximum 1.38 mGy for68Ga and 66.0 mGy for111In. The two sources mainly contributing to the islet absorbed dose are the kidneys (33–61%) and the islet self-dose (7.5–57%). In conclusion, all islet absorbed doses are low (<70 mGy), so even repeated imaging will hardly increase the risk on diabetes.