The Simple Preparation of Polyethylene Glycol-Based Soft Nanoparticles Containing Dual Imaging Probes.
The Simple Preparation of Polyethylene Glycol-Based Soft Nanoparticles Containing Dual Imaging Probes.
复制标题
含有双成像探针的聚乙二醇基软纳米颗粒的简单制备。
DOI：
10.1039/c3tb20828a
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kato M.
中科院分区：
文献类型：
--
作者：
Murayama S;Jo JI;Shibata Y;Liang K;Santa T;Saga T;Aoki I;Kato M.
We developed a simple method to prepare PEG-based soft nanoparticles that encapsulate dual imaging probes. Because the probes could be encapsulated by either chemical or physical means, a variety of probe molecules were encapsulated within the nanoparticles simultaneously. The nanoparticles were administrated to mice and the pharmacokinetics of the nanoparticles was analyzed by means of MRI, fluorescence spectroscopy, and transmission electron microscopy. The soft nanoparticles were excreted by the mice rapidly through the urine without collapse of the nanoparticles and without leaking of the probe molecules, and no accumulation of the nanoparticles in the body was observed. The pharmacokinetics of the nanoparticles was not changed by the encapsulated molecules and acute toxicity to mice was negligible. It was expect that these PEG-based soft nanoparticles will be applicable for use as a safe diagnostic agent.
