Natural Killers Are Made Not Born: How to Exploit NK Cells in Lung Malignancies.
Natural Killers Are Made Not Born: How to Exploit NK Cells in Lung Malignancies.
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DOI：
10.3389/fimmu.2017.00277
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发表时间：
2017
影响因子：
7.3
通讯作者：
Ferlazzo G
中科院分区：
文献类型：
--
作者：
Carrega P;Ferlazzo G
近年来，自然杀伤(NK)细胞在肺部恶性肿瘤中的特征研究取得了一些进展，对NK细胞在肺部肿瘤中的分布、分布、表型和功能状态有了更深入的了解。肺癌中募集的NK细胞亚群主要能够产生相关的细胞因子，而不是直接杀伤癌细胞。因此，NK细胞在肿瘤微环境中的作用也可能超越了对肿瘤细胞的杀伤作用，是被赋予对大量免疫效应分子的调节功能的NK细胞。然而，增强它们的细胞毒性功能，并将细胞毒性NK细胞亚群重新定向到肿瘤部位，可能会为肺癌开辟新的治疗途径。此外，我们认为，现在需要更深入地研究传统疗法(如化疗)和新疗法(如抗免疫检查点单抗)对肺癌患者NK细胞稳态的影响。
In recent years, progress has been made in the characterization of natural killer (NK) cells in lung malignancies, and we have now gained a better understanding of the frequency, localization, phenotype, and functional status of NK cells infiltrating these tumors. NK cell subset recruited in lung cancer is mainly capable of producing relevant cytokines rather than exerting direct cancer cell killing. Thus, the relevance of NK cells in tumor microenvironment might also go beyond the killing of tumor cells, being NK cells endowed with regulatory functions toward an ample array of immune effectors. Nevertheless, boosting their cytotoxic functions and redirecting the migration of cytotoxic NK cell subset to the tumor site might open new therapeutic avenues for lung cancer. Also, we believe that a deeper investigation into the impact of both conventional (e.g., chemotherapy) or new therapies (e.g., anti-immune checkpoints mAbs) on NK cell homeostasis in lung cancer patients is now required.