Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome
Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome
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DOI：
10.1016/j.nut.2015.11.001
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发表时间：
2016-06-01
期刊：
影响因子：
4.4
通讯作者：
Costa, Giselle Nobre
中科院分区：
文献类型：
--
作者：
Bernini, Luciana Jesus;Colado Simao, Andrea Name;Costa, Giselle Nobre
目的：人体研究已经表明益生菌微生物对代谢综合征（MetS）和其他心血管风险的参数的有益作用，但据我们所知，尚未报道乳双歧杆菌的作用。本研究的目的是评估食用含有益生菌B的牛奶的效果。方法：选择51例代谢综合征患者，随机分为对照组（n = 25）和益生菌组（n = 26）。益生菌组在45 d内饮用含有益生菌的发酵乳。B的影响。乳酸对血脂谱，葡萄糖代谢和促炎细胞因子（肿瘤坏死因子-α和白细胞介素-6）进行了评估，在基线和45天后的个人的血液样本。结果：每天摄入80毫升发酵牛奶与2.72 × 1010菌落形成单位的B。与基线和对照组值相比，乳酸菌HNO 19显示体重指数（P = 0.017）、总胆固醇（P = 0.009）和低密度脂蛋白（P = 0.008）显著降低。此外，肿瘤坏死因子-α（P = 0.033）和白细胞介素-6（P = 0.044）的促炎细胞因子观察到显着下降。结论：这些数据显示了潜在的影响B。乳酸HNO 19在降低肥胖、血脂和一些炎症标志物方面的作用，这可能降低MetS患者的心血管风险。(C)2016 Elsevier Inc. All rights reserved.
Objective: Human studies have shown the beneficial effects of probiotic microorganisms on the parameters of metabolic syndrome (MetS) and other cardiovascular risks, but to our knowledge the effect of Bifidobacterium lactis has not yet been reported. The aim of this study was to evaluate the effect of consumption of milk containing the probiotic B. lactis HNO19 on the classical parameters of MetS and other related cardiovascular risk factors.Methods: Fifty-one patients with MetS were selected and divided into a control group (n = 25) and a probiotic group (n = 26). The probiotic group consumed fermented milk with probiotics over the course of 45 d. The effects of B. lactis on lipid profile, glucose metabolism, and proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) were assessed in blood samples of the individuals at the baseline and after 45 d.Results: Daily ingestion of 80 mL fermented milk with 2.72 x 1010 colony-forming units of B. lactis HNO19 showed significant reduction in body mass index (P = 0.017), total cholesterol (P = 0.009), and low-density lipoprotein (P = 0.008) compared with baseline and control group values. Furthermore, a significant decrease in tumor necrosis factor-alpha (P = 0.033) and interleukin-6 (P = 0.044) proinflammatory cytokines was observed.Conclusion: These data showed potential effects of B. lactis HNO19 in reducing obesity, blood lipids, and some inflammatory markers, which may reduce cardiovascular risk in patients with MetS. (C) 2016 Elsevier Inc. All rights reserved.