Seasonal variation in salivary cortisol but not symptoms of depression and trait anxiety in pregnant women undergoing an elective caesarean section
Seasonal variation in salivary cortisol but not symptoms of depression and trait anxiety in pregnant women undergoing an elective caesarean section
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DOI：
10.1016/j.psyneuen.2019.05.029
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发表时间：
2019-10-01
影响因子：
3.7
通讯作者：
John, Rosalind M.
中科院分区：
文献类型：
--
作者：
Garay, Samantha M.;Savory, Katrina A.;John, Rosalind M.
目的：情绪和行为的季节性变化通常在普通人群中被报道，但关于季节性和怀孕的知之甚少。这项研究调查了居住在南威尔士的孕妇的抑郁和焦虑症状、唾液皮质醇浓度、定制出生体重百分位数(CBWC)和胎盘重量与季节的关系。方法：本研究利用纵向生长在威尔士(GIW)队列中的数据。女性在手术前选择性剖腹产(ELCS)预约时被招募，当时她们提供唾液样本，并完成爱丁堡产后抑郁量表(EPDS)和状态-特质焦虑量表(STAI)的特质子量表(STAI)。有关出生体重和胎盘重量的数据摘自医学笔记。结果：季节与EPDS(p=.178)、STAI评分(p=.544)、CBWC(p=.683)或胎盘重量(p=.857)之间没有关联。不同季节和唾液皮质醇浓度(p<；.001)之间存在显著差异，秋季和冬季的水平最高。与秋季、春季(B=-0.05，p=0.009，95%CI-09，-01)和夏季(B=-06，p=.002，95%CI-.10，结论：这项研究发现季节与母亲报告的心理健康症状、新生儿出生体重或胎盘重量之间没有关联，但季节和足月唾液皮质醇之间存在关联。这一发现将对使用唾液皮质醇作为生物标记物时不考虑季节性的研究产生影响。
Objectives: Seasonal changes in mood and behaviour are commonly reported in the general population but considerably less is known regarding seasonality and pregnancy. This study investigated the relationship between seasons and depression and anxiety symptoms, salivary cortisol concentrations, custom birthweight centiles (CBWC) and placenta weight for pregnant women living in South Wales.Methods: This study utilised data from the longitudinal Grown in Wales (GiW) cohort. Women were recruited at the presurgical elective caesarean section (ELCS) appointment, when they provided saliva samples and completed the Edinburgh Postnatal Depression Scale (EPDS) and trait subscale of the State-Trait Anxiety Inventory (STAI). Data on birthweight and placental weight was extracted from medical notes. Seasonal data was available for 316 participants.Results: No association was identified between seasons and EPDS (p = .178), STAI scores (p = .544), CBWC (p = .683) or placental weight (p = .857). Significance was identified between seasons and salivary cortisol concentration (p < .001), with highest levels in autumn and winter. Adjusted linear regression identified spring (B= -.05, p = .007, 95% CI -.09, -.01) and summer (B= -.06, p = .001, 95% CI -09, -.02) compared to autumn, and spring (B= - .05, p= .009, 95% CI -.09, - .01) and summer (B= -.06, p= .002, 95% CI - .10, - .02) compared to winter to be associated with decreased cortisol concentrations.Conclusion: This study found no association between season and maternally-reported mental health symptoms, birthweight by CBWC or placental weight but did between season and term salivary cortisol. This finding will have implications for studies that do not account for seasonality when using salivary cortisol as a biomarker.