Icodextrin'S Effects on Peritoneal Transport
Icodextrin'S Effects on Peritoneal Transport
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艾考糊精对腹膜转运的影响
DOI：
10.1177/089686089701700110
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发表时间：
1997
影响因子：
2.8
通讯作者：
A. L. Imholz
中科院分区：
文献类型：
--
作者：
R. Krediet;M. M. Ho;A. L. Imholz
目的概述腹膜液体转运的一般原理，分析二十碳糊精对液体和溶质转运的影响。设计：回顾阿姆斯特丹学术医学中心有关二十碳糊精对持续不卧床腹膜透析(CAPD)患者疗效的文献和数据。结果Icodextrin对低分子溶质的传质面积系数无影响。对白蛋白和较大的血清蛋白的清除也没有影响。由于对流输运，β-2-微球蛋白在二十碳糊精溶液中的清除量大于葡萄糖溶液。在长时间停留期间、腹膜炎期间以及因腹膜有效表面积大而导致超滤失败的患者中，Icodextrin在诱导净超滤方面尤其优于葡萄糖。结论Icodextrin对腹膜通透性无明显影响，但增加了小孔系统的对流流量。因此，β-2-微球蛋白的腹膜清除率高于葡萄糖溶液。lcodextrin特别适用于长期使用和因腹膜表面积较大而导致超滤功能受损的患者，从而导致低分子溶质的高转运速率。
Objective To give a survey of the principles of peritoneal fluid transport in general, followed by an analysis of the effects of icodextrin on the transport of fluid and solutes. Design A review of the literature and of data on the effects of icodextrin in continuous ambulatory peritoneal dialysis (CAPD) patients at the Academic Medical Center, Amsterdam. Results Icodextrin had no effect on the mass transfer area coefficients of low molecular weight solutes. Also no effect was found on the clearances of albumin and larger serum proteins. Due to convective transport, the clearance of β2-microglobulin was greater with icodextrin than with glucose solutions. Icodextrin was especially superior to glucose in the induction of net ultrafiltration during long dwells, during peritonitis, and in patients with ultrafiltration failure caused by a large effective peritoneal surface area. Conclusion Icodextrin has no effect on the permeability characteristics of the peritoneal membrane, but increases convective flow through the small-pore system. As a result, the peritoneal clearance of β2-microglobulin is higher than with glucose-based solutions.lcodextrin is especially indicated for long dwells and in patients with impaired ultrafiltration caused by a large peritoneal surface area, leading to high transport rates of low molecular weight solutes.