A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans.
A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans.
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DOI：
10.1007/s12603-012-0084-2
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Miller DK
中科院分区：
文献类型：
--
作者：
Morley JE;Malmstrom TK;Miller DK
对脆弱量表进行效度检验。纵向研究。社区。研究开始时年龄在49岁到65岁之间的非洲裔美国人的代表性样本。5项疲劳量表(疲劳、抵抗、行走、疾病和体重减轻)，基线和9年时日常生活能力(ADLS)、工具性日常生活能力(IADLS)、死亡率、短身体活动能力(SPPB)、步速、单腿站立、握力和损伤性跌倒。基线时抽血检测CRP、SIL6R、STNFR1、sTNFR2和25(OH)维生素D。在横断面上，在没有基线ADL困难的参与者中，脆弱程度与IADL困难、SPPB、握力和单腿站立显著相关(N=703)，而在那些没有基线ADL依赖的参与者中，这些结果加上步速(N=883)显著相关。TNFR1在衰弱前期和衰弱组升高，CRP在某些亚组升高。纵向(N=423，无基线ADL困难或N=528，无基线ADL依赖)，并根据基线值进行调整，基线前虚弱显著预测两组未来的ADL困难、更差的单腿站立评分和死亡率，以及依赖排除组的IADL困难。在两组中，在基线时身体虚弱显著预示着未来的ADL困难、IADL困难和死亡率，以及在排除依赖的组中更糟糕的SPPB。这项研究在一群中年晚期的非洲裔美国人中验证了脆弱的量表。这一简单的5个问题量表是临床医生的一种极好的筛查测试，以确定有可能发展为残疾以及健康功能和死亡率下降的体弱者。
To validate the FRAIL scale. Longitudinal study. Community. Representative sample of African Americans age 49 to 65 years at onset of study. The 5-item FRAIL scale (Fatigue, Resistance, Ambulation, Illnesses, & Loss of Weight), at baseline and activities of daily living (ADLs), instrumental activities of daily living (IADLs), mortality, short physical performance battery (SPPB), gait speed, one-leg stand, grip strength and injurious falls at baseline and 9 years. Blood tests for CRP, SIL6R, STNFR1, STNFR2 and 25 (OH) vitamin D at baseline. Cross-sectionally the FRAIL scale correlated significantly with IADL difficulties, SPPB, grip strength and one-leg stand among participants with no baseline ADL difficulties (N=703) and those outcomes plus gait speed in those with no baseline ADL dependencies (N=883). TNFR1 was increased in pre-frail and frail subjects and CRP in some subgroups. Longitudinally (N=423 with no baseline ADL difficulties or N=528 with no baseline ADL dependencies), and adjusted for the baseline value for each outcome, being pre-frail at baseline significantly predicted future ADL difficulties, worse one-leg stand scores, and mortality in both groups, plus IADL difficulties in the dependence-excluded group. Being frail at baseline significantly predicted future ADL difficulties, IADL difficulties, and mortality in both groups, plus worse SPPB in the dependence-excluded group. This study has validated the FRAIL scale in a late middle-aged African American population. This simple 5-question scale is an excellent screening test for clinicians to identify frail persons at risk of developing disability as well as decline in health functioning and mortality.