Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE.
Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE.
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DOI：
10.1038/nrrheum.2014.6
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发表时间：
2014-04
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影响因子：
--
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中科院分区：
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已有的和新出现的数据表明，在临床类风湿性关节炎（RA）和系统性红斑狼疮（SLE）以及其他自身免疫性风湿性疾病（ARDs）的发病之前，疾病的“临床前”阶段的特征在于在临床明显体征和症状发作之前疾病相关生物标志物的异常。许多遗传和环境的风险因素也已确定的ARDs，这些因素中的许多很可能在组织损伤的临床表现开始和/或传播自身免疫性和自身免疫性疾病。因此，代表这些自身免疫过程的生物标志物可能在ARDs的临床前阶段与其他临床参数结合使用，以预测临床明显疾病的未来发展。本综述主要关注RA和SLE的临床前阶段，因为我们目前对这些疾病的了解可用于提出ARDs发展的总体模型，最终可用于制定筛查计划和预防策略。还讨论了今后发展这种方法的重要考虑因素，特别是需要进一步研究的问题以及如何解决这些问题。
Established and emerging data demonstrate that a ‘preclinical’ period of disease precedes the onset of clinical rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as well as other autoimmune rheumatic diseases (ARDs).This preclinical stage of development of disease is characterized by abnormalities in disease-related biomarkers before the onset of the clinically apparent signs and symptoms. Numerous genetic and environmental risk factors for ARDs have also been identified, and many of these factors are likely to act before the clinical appearance of tissue injury to initiate and/or propagate autoimmunity and autoimmune disease. Thus, biomarkers representative of these autoimmune processes could potentially be used in conjunction with other clinical parameters during the preclinical period of ARDs to predict the future development of clinically apparent disease. This Review focuses on the preclinical stages of RA and SLE, as our current understanding of these diseases can be used to present an overall model of the development of ARDs that might ultimately be used to develop screening programmes and preventive strategies. Important considerations for the future development of such approaches, in particular, the issues that require additional research and how they might be addressed, are also discussed.
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影响因子：
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作者：
Agarwal, Sandeep K.
通讯作者：
Agarwal, Sandeep K.
影响因子：
158.5
作者：
Arbuckle, MR;McClain, MT;Harley, JB
通讯作者：
Harley, JB
DOI：
10.4049/jimmunol.1001983
发表时间：
2011-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chang A;Henderson SG;Brandt D;Liu N;Guttikonda R;Hsieh C;Kaverina N;Utset TO;Meehan SM;Quigg RJ;Meffre E;Clark MR
通讯作者：
Clark MR
DOI：
10.3899/jrheum.080895
发表时间：
2009-04
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Chibnik LB;Mandl LA;Costenbader KH;Schur PH;Karlson EW
通讯作者：
Karlson EW
影响因子：
2.3
作者：
Birnbaum, Howard;Pike, Crystal;Cifaldi, Mary
通讯作者：
Cifaldi, Mary