Development of Ultra-High Dose-Rate (FLASH) Particle Therapy.
Development of Ultra-High Dose-Rate (FLASH) Particle Therapy.
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DOI：
10.1109/trpms.2021.3091406
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发表时间：
2022-03
影响因子：
4.4
通讯作者：
Petersson, Kristoffer
中科院分区：
文献类型：
--
作者：
Kim, Michele M.;Darafsheh, Arash;Schuemann, Jan;Dokic, Ivana;Lundh, Olle;Zhao, Tianyu;Ramos-Mendez, Jose;Dong, Lei;Petersson, Kristoffer
关键词：
最近，FLASH 放射治疗的研究工作加速增加。 FLASH放疗涉及超高剂量率，与传统剂量率放疗相比，临床前研究表明，FLASH放疗可降低对正常组织的毒性，同时保持肿瘤反应。本综述的目的是总结迄今为止进行的质子、电子和重离子闪光放射治疗的研究，特别强调每项研究的物理方面以及每种治疗方式的优缺点。描述了每种 FLASH 模式的光束传输参数、实验设置和使用的剂量测定工具。此外，还讨论了 FLASH 放射治疗的建模工作和治疗计划，以及转化为临床环境时的潜在缺点。最后一部分总结了在安全临床实施 FLASH 放射治疗之前尚未回答的进一步问题。
Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH radiotherapy.
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