Contribution of alternative splicing to breast cancer metastasis.
Contribution of alternative splicing to breast cancer metastasis.
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DOI：
10.20517/2394-4722.2018.96
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Yu, Huimin
中科院分区：
文献类型：
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作者：
Meng, Xiangbing;Yang, Shujie;Yu, Huimin
选择性剪接是真核生物转录组和蛋白质组多样性的主要贡献者。与正常样本相比，最近在癌症基因组图谱数据库中包含的 32 种癌症类型中发现了大约 30% 的选择性剪接事件。一些选择性剪接异构体及其编码的蛋白质有助于形成特定的癌症特征。在这篇综述中，我们将讨论选择性剪接对乳腺癌转移的贡献的最新进展。我们计划剖析 MTDH、CD44 的作用及其与其他 mRNA 剪接因子的相互作用。我们相信，深入了解剪接对乳腺癌转移的作用机制将为乳腺癌的治疗提供新的策略。
Alternative splicing is a major contributor to transcriptome and proteome diversity in eukaryotes. Comparing to normal samples, about 30% more alternative splicing events were recently identified in 32 cancer types included in The Cancer Genome Atlas database. Some alternative splicing isoforms and their encoded proteins contribute to specific cancer hallmarks. In this review, we will discuss recent progress regarding the contributions of alternative splicing to breast cancer metastasis. We plan to dissect the role of MTDH, CD44 and their interaction with other mRNA splicing factors. We believe an in-depth understanding of the mechanism underlying the contribution of splicing to breast cancer metastasis will provide novel strategies to the management of breast cancer.