Competing for memory:: Hippocampal LTP under regimes of reduced protein synthesis
Competing for memory:: Hippocampal LTP under regimes of reduced protein synthesis
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DOI：
10.1016/s0896-6273(04)00713-5
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发表时间：
2004-12-16
期刊：
影响因子：
16.2
通讯作者：
Bonhoeffer, T
中科院分区：
文献类型：
--
作者：
Fonseca, R;Nägerl, UV;Bonhoeffer, T
海马突触增强的持久性取决于转录和蛋白质合成。我们在这里报道，在蛋白质合成减少的情况下，突触之间对相关细胞内蛋白质的竞争可以被证明。在这种情况下，对于一组给定的突触后神经元，诱导额外的蛋白质合成依赖的长期增强发生在以维持独立通路上的先前增强为代价的情况下。这种新现象，我们称之为“竞争性维持”，具有重要的功能后果，它可以用突触和“可塑性因素”在长时间内的动态相互作用来解释。
The persistence of synaptic potentiation in the hippocampus is known to depend on transcription and protein synthesis. We report here that, under regimes of reduced protein synthesis, competition between synapses for the relevant intracellular proteins can be demonstrated. Under such circumstances, the induction of additional protein synthesis-dependent long-term potentiation for a given set of postsynaptic neurons occurs at the expense of the maintenance of prior potentiation on an independent pathway. This new phenomenon, which we call "competitive maintenance," has important functional consequences, and it may be explained in terms of dynamic interactions between synapses and "plasticity factors" over extended periods of time.