THE ASSOCIATION BETWEEN RENAL DYSFUNCTION AND OSTEOPENIA IN ENVIRONMENTAL CADMIUM-EXPOSED SUBJECTS
THE ASSOCIATION BETWEEN RENAL DYSFUNCTION AND OSTEOPENIA IN ENVIRONMENTAL CADMIUM-EXPOSED SUBJECTS
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DOI：
10.1016/s0013-9351(05)80183-5
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发表时间：
1990-02-01
影响因子：
8.3
通讯作者：
NAKAGAWA, H
中科院分区：
文献类型：
--
作者：
KIDO, T;NOGAWA, K;NAKAGAWA, H
对203例镉接触者和80例非镉接触者的肾功能损害进行了检查，以揭示镉引起的肾功能损害与骨量减少之间的关系。作为肾功能的生物学指标，选择尿B2-微球蛋白（β 2-mg）和血清肌酐、钙和磷。尿和血中镉也进行了测定。结果表明，男女之间存在显着差异，在镉暴露以及非暴露的主题。为了评估骨质减少的程度，使用显微密度计（MD）方法。采用多因素分析法分析生物学参数与MD法各指标之间的关系。年龄、尿β 2-mg和血清肌酐与Cd暴露男性的骨质减少指数显著相关。相反，年龄与两组女性的MD指数相关性最显著。然而，尿β 2-mg仅在Cd暴露的妇女中与MD指数显著相关。在Cd暴露的受试者中，在预测变量的数量增加后，尿β 2-mg也与骨质减少强烈相关。这些结果表明镉暴露受试者肾功能不全和骨质减少之间存在因果关系。
Two hundred and three cadmium (Cd)-exposed subjects with renal dysfunction and 80 non-exposed subjects were examined to reveal the relationship between Cd-induced renal dysfunction and osteopenia. As biological indicators of renal function, urinary B2-microglobulin (.beta.2-mg), and serum creatinine, calcium, and phosphorus were selected. Cd in the urine and blood was also measured. The results indicated that significant differences exist between both sexes in Cd-exposed as well as nonexposed subjects. To evaluate the degree of osteopenia, a microdensitometrical (MD) method was used. The relationships between biological parameters and each index of the MD method were analyzed using multivariate analysis. Age, urinary .beta.2-mg, and serum creatinine were significantly associated with indices of osteopenia in Cd-exposed men. In contrast, age showed the most significant association with MD indices in women of both groups. However, urinary .beta.2-mg was significantly associated with MD indices only in Cd-exposed women. In Cd-exposed subjects, after the number of predictor variables was increased, urinary .beta.2-mg was also strongly associated with osteopenia. These results suggest a causal relationship between renal dysfunction and osteopenia in Cd-exposed subjects.