Vitamin D3 in fat tissue
Vitamin D3 in fat tissue
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DOI：
10.1007/s12020-008-9051-4
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发表时间：
2008-04-01
期刊：
影响因子：
3.7
通讯作者：
Dawson-Hughes, Bess
中科院分区：
文献类型：
--
作者：
Blum, Miriam;Dolnikowski, Gregory;Dawson-Hughes, Bess
描述脂肪组织中维生素D含量的文献极为有限。我们进行了一项初步研究，测量了肥胖成年人脂肪组织和血清中维生素D-3的浓度。使用新的液相色谱质谱法（LC/MS）进行这些测量。本研究的目的是：测量和报告肥胖个体血清和皮下脂肪样本中的维生素D-3浓度，并检查脂肪中维生素D-3与血清中维生素D-3的相关性。这项横断面研究在17名计划接受胃旁路手术的肥胖男性和女性中进行。受试者皮下脂肪组织样本中的平均维生素D-3浓度为102.8 +/- 42.0 nmol/kg。血清中维生素D-3的平均浓度为7.78 +。3.99 nmol/l。脂肪组织和血清中维生素D-3浓度呈正相关（r = 0.68，P = 0.003）。与肥胖受试者的既往研究结果一致，本研究中的受试者维生素D状态欠佳，表现为平均25-羟基维生素D浓度为43.3 +/- 15.4 nmol/l。总之，脂肪组织维生素D-3可以通过LC/MS测量，并且在维生素D状态不佳的肥胖受试者中是可检测的。与长期存在的脂肪组织是维生素D储存场所的概念相一致，脂肪组织和血清维生素D-3浓度呈正相关。
The literature describing vitamin D content of fat tissue is extremely limited. We conducted a pilot study that measured the concentrations of vitamin D-3 in the fat tissue and serum of obese adults. These measurements were performed using a new liquid chromatography mass spectrometry (LC/MS) method. The objectives of this study were: to measure and report the vitamin D-3 concentration in serum and subcutaneous fat samples from obese individuals and to examine the association of vitamin D-3 in fat with vitamin D-3 in serum. This cross-sectional study was conducted in 17 obese men and women who were scheduled to undergo gastric bypass surgery. The mean vitamin D-3 concentration in subjects' subcutaneous fat tissue samples was 102.8 +/- 42.0 nmol/kg. The mean vitamin D-3 concentration in serum was 7.78 +.- 3.99 nmol/l. Vitamin D-3 concentrations of fat tissue and serum were positively correlated (r = 0.68, P = 0.003). Consistent with previous findings in obese subjects, subjects in this study had suboptimal vitamin D status as demonstrated by a mean 25-hydroxyvitamin D concentration of 43.3 +/- 15.4 nmol/l. In conclusion, fat tissue vitamin D-3 can be measured by LC/MS and is detectable in obese subjects with suboptimal vitamin D status. Compatible with the long-standing concept that fat tissue is a storage site for vitamin D, fat tissue and serum vitamin D-3 concentrations were positively correlated.