Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3
Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3
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DOI：
10.1016/s0168-3659(02)00356-5
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发表时间：
2003-02-21
影响因子：
10.8
通讯作者：
Borchard, G
中科院分区：
文献类型：
--
作者：
Florea, BI;Cassara, ML;Borchard, G
肺部药物递送有两个目的，即应用局部活性化合物来治疗肺部疾病，以及利用肺上皮作为大分子药物的吸收位点。为了在细胞水平上阐明化合物肺部吸收和代谢的机制，细胞培养模型已被证明虽然有限，但在预测体内条件方面相当有用。最近，Calu-3 细胞系在许多药物转运和代谢研究中被用作气道上皮细胞的模型。本文介绍了这些研究的结果以及对模型预测效力的评估。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Pulmonary drug delivery serves two purposes, namely the application of locally active compounds for treatment of diseases afflicting the lung, and the utilization of the pulmonary epithelia as absorption sites for macromolecular drugs. To elucidate the mechanisms involved in the pulmonary absorption and metabolism of compounds on a cellular level, cell culture models have shown to be, though limited, rather useful in predicting in vivo conditions. The Calu-3 cell line has been employed recently as a model for the airway epithelium in a number of drug transport and metabolism studies. The results of these studies, as well as an evaluation of the predictive potency of the model, are presented here. (C) 2002 Elsevier Science B.V. All rights reserved.