Independent Control of Topography for 3D Patterning of the ECM Microenvironment.
Independent Control of Topography for 3D Patterning of the ECM Microenvironment.
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DOI：
10.1002/adma.201503950
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发表时间：
2016-01-06
期刊：
影响因子：
--
通讯作者：
Tanner K
中科院分区：
文献类型：
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作者：
Kim J;Staunton JR;Tanner K
制备了由ECM蛋白包被磁珠的磁场定向自组装驱动的仿生细胞外基质（ECM）形貌。这种新颖的自下而上的方法使我们能够编程各向同性，各向异性和各种混合ECM模式，而不改变支架材料的其他物理化学性质。结果表明，这种三维各向异性基质能够引导细胞的树突状突起。
Biomimetic extracellular matrix (ECM) topographies driven by the magnetic‐field‐directed self‐assembly of ECM protein‐coated magnetic beads are fabricated. This novel bottom‐up method allows us to program isotropic, anisotropic, and diverse hybrid ECM patterns without changing other physicochemical properties of the scaffold material. It is demonstrated that this 3D anisotropic matrix is able to guide the dendritic protrusion of cells.