Hepatitis B virus and risk of non-Hodgkin lymphoma: An updated meta-analysis of 58 studies
Hepatitis B virus and risk of non-Hodgkin lymphoma: An updated meta-analysis of 58 studies
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乙型肝炎病毒与非霍奇金淋巴瘤的风险：58 项研究的最新荟萃分析
DOI：
10.1111/jvh.12892
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发表时间：
2018-08-01
影响因子：
2.5
通讯作者：
Tu, H.
中科院分区：
文献类型：
--
作者：
Li, M.;Gan, Y.;Tu, H.
以往的研究主要集中在B型肝炎病毒（HBV）感染与非霍奇金淋巴瘤（NHL）之间的关系。然而，结果仍然不一致，在不同的亚组中有些冲突。本研究的目的是联合收割机的独立研究的结果，全面评估HBV和NHL之间的关联使用荟萃分析。通过结构化关键词检索PubMed、EMBASE和中国知网（CNKI）数据库确定相关研究，最终纳入58篇研究，共53714例NHL病例和1778591例对照。合并估计值表明，无论研究设计如何，HBV感染个体的NHL风险均显著增加（汇总比值比[sOR]：2.50; 95%置信区间[CI]：2.20-2.83）（病例对照研究：sOR：2.47; 95% CI：2.16-2.82;队列研究：sOR：2.64; 95% CI：1.78-3.91）。在研究中观察到相当大的异质性，主要归因于NHL亚型（荟萃回归：P
Previous studies have focused on the relationship between hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL). However, the results remain inconsistent and somehow conflicting in different subgroups. The aim of this study was to combine the findings of independent studies to comprehensively assess the association between HBV and NHL using a meta-analysis. Relevant studies were identified through structured keyword searches in PubMed, EMBASE and the China National Knowledge Infrastructure (CNKI) database, and 58 studies with a total of 53714 NHL cases and 1778591 controls were finally included. Pooled estimates indicated a significantly increased NHL risk in HBV-infected individuals (summary odds ratio [sOR]: 2.50; 95% confidence interval [CI]: 2.20-2.83) regardless of the study design (case-control studies: sOR: 2.47; 95% CI: 2.16-2.82; cohort studies: sOR: 2.64; 95% CI: 1.78-3.91). Considerable heterogeneity was observed across studies that was primarily attributed to the NHL subtypes (meta-regression: P