Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway
Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway
复制标题
核糖体蛋白S15A通过p53信号通路的错误调节促进结直肠癌的恶性转化并预测不良结果
DOI：
10.3892/ijo.2016.3366
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发表时间：
2016-04-01
影响因子：
5.2
通讯作者：
Qin, Xinyu
中科院分区：
文献类型：
--
作者：
Chen, Jingwen;Wei, Ye;Qin, Xinyu
核糖体蛋白S15A（RPS15A）是一种高度保守的40 S核糖体蛋白，对细胞的生存和增殖至关重要。本研究评估了RPS15A在结直肠癌（CRC）中的功能作用，我们的调查发现RPS15A在人类CRC队列中高度表达。RPS15A高表达与年龄较大（P=0.035）、术前未接受新辅助治疗（P=0.048）、原发pN分期较高（P=0.007）和同步远处转移稍多（P=0.058）相关。考克斯单因素和多因素风险回归分析显示，RPS15 A高表达导致结直肠癌患者总生存率降低，提示RPS15 A高表达是结直肠癌患者预后的独立危险因素（P
Ribosomal protein S15A (RPS15A), which has been identified as a highly conserved 40S ribosomal protein, is essential for cell survival and proliferation. The present study evaluated the functional role of RPS15A in colorectal cancer (CRC), and our investigation found that RPS15A was highly expressed in a cohort of human CRC. High RPS15A expression was associated with older age (P=0.035), not receiving preoperative neoadjuvant treatment (P=0.048), higher primary pN stage (P=0.007) and slightly more synchronous distant metastases (P=0.058). The Cox univariate and multivariate hazard regression analysis revealed that higher expression of RPS15A led to a reduction of overall survival rate in CRC, indicating that enhanced RPS15A expression functions as an independent risk factor for the prognosis of CRC patients (P