Partial recovery of visual extinction by pavlovian conditioning in a patient with hemispatial neglect
Partial recovery of visual extinction by pavlovian conditioning in a patient with hemispatial neglect
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DOI：
10.1016/j.cortex.2012.11.005
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发表时间：
2013-03-01
期刊：
影响因子：
3.6
通讯作者：
Vuilleumier, Patrik
中科院分区：
文献类型：
--
作者：
Dominguez-Borras, Judith;Armony, Jorge L.;Vuilleumier, Patrik
患有顶叶病变和单侧空间忽视(USN)的患者无法检测或对空间对侧的信息做出反应。然而，当相反的刺激在感知上或生物上显著时，一些残留的感觉处理仍然可能发生，并克服注意力不集中的症状，如情绪面孔或声音所显示的。这些效应被归因于感觉区域对情绪刺激的神经反应增强，推测是由杏仁核等边缘区域的反馈信号驱动的。然而，由于情绪面孔和声音在生理特征上也不同于中性刺激，这些效应的情感本质仍有待证实。在这里，我们报告了一例右顶叶患者的数据，在巴甫洛夫厌恶条件作用后，相对于条件作用前的相同刺激，以及类似的非条件刺激，对侧视觉刺激的左侧视觉消退减少。这一减少。因此，视觉消退是通过内隐学习获得的刺激的情感意义所中介的。功能磁共振成像还显示，与非条件刺激相比，条件视觉刺激在右侧视觉皮质中引发了更大的激活，同时杏仁核也出现了不同的激活。这些结果支持这样一种假设，即情绪评估不仅是对知觉特征的加工，还可以部分恢复对对侧空间中显著信息的注意。这些发现为改进基于情感和动机信号的忽视的康复策略开辟了新的视角。(C)2012爱思唯尔有限公司。保留所有权利。
Patients with parietal lesions and unilateral spatial neglect (USN) are unable to detect or respond to information in the contralesional side of space. However, some residual sensory processing may still occur and overcome inattention symptoms when contralesional stimuli are perceptually or biologically salient, as shown for emotional faces or voices. These effects have been attributed to enhanced neural responses of sensory regions to emotional stimuli, presumably driven by feedback signals from limbic regions such as the amygdala. However, because emotional faces and voices also differ from neutral stimuli in terms of physical features, the affective nature of these effects still remains to be confirmed. Here we report data from a right parietal patient in whom left visual extinction was reduced for contralesional visual stimuli following pavlovian aversive conditioning, relative to the same stimulus before conditioning, and relative to similar but non-conditioned stimuli. This reduction of. visual extinction was thus mediated by the emotional meaning of stimuli acquired through implicit learning. Functional magnetic resonance imaging also showed that conditioned visual stimuli elicited greater activation in right visual cortex, relative to the non-conditioned stimuli, together with differential activations in amygdala. These results support the hypothesis that emotional appraisal, not only the processing of perceptual features, may partly restore attention to salient information in contralesional space. These findings open new perspectives to improve rehabilitation strategies in neglect, based on affective and motivational signals. (c) 2012 Elsevier Ltd. All rights reserved.