APOLIPOPROTEIN E4 ALLELE IN A POPULATION-BASED STUDY OF EARLY-ONSET ALZHEIMERS-DISEASE
APOLIPOPROTEIN E4 ALLELE IN A POPULATION-BASED STUDY OF EARLY-ONSET ALZHEIMERS-DISEASE
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DOI：
10.1038/ng0594-74
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发表时间：
1994-05-01
期刊：
影响因子：
30.8
通讯作者：
VAN BROECKHOVEN, C
中科院分区：
文献类型：
--
作者：
VANDUIJN, CM;DEKNIJFF, P;VAN BROECKHOVEN, C
一些研究报道了载脂蛋白E等位基因epsilon 4 （APOE*4）与家族性和散发性晚发性阿尔茨海默病（LOAD）的关联。在此，我们报告了APOE*4与早发性阿尔茨海默病（EOAD）之间的关系，这是一项基于荷兰人群的研究。APOE*4等位基因的频率在EOAD病例中是对照组的2.3倍。在患者中，有阳性家族史者的等位基因频率是无家族史者的1.6倍。与痴呆家族史无关，APOE*4纯合子受试者的EOAD风险显著增加，而APOE*4杂合子受试者的EOAD风险仅在家族史阳性的受试者中才会增加。我们的研究表明APOE*4与EOAD之间存在显著关联，这种关联受痴呆家族史的影响。
Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele frequency was 1.6 times higher in those with a positive family history than in those without. A significant increase in risk of EOAD was found for subjects homozygous for APOE*4 regardless of family history of dementia, but an increase in EOAD risk for APOE*4 heterozygotes could only be shown in subjects with a positive family history. Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia.