Corrigendum to "Metabolic Syndrome, Inflammation, and Cancer".
Corrigendum to "Metabolic Syndrome, Inflammation, and Cancer".
复制标题
“代谢综合征、炎症和癌症”勘误表。
DOI：
10.1155/2017/6598540
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发表时间：
2017
影响因子：
4.6
通讯作者：
Deng,Lin
中科院分区：
文献类型：
--
作者：
Wu,Yong;Dong,Yunzhou;Duan,Shengzhong;Zhu,Donghui;Deng,Lin
与超重/肥胖相关的炎症状况代表代谢综合征发病机制中的触发因素，并且主要促成相关病理结果。营养过剩、缺乏运动和衰老等刺激可能导致促炎细胞因子分泌过多，最终导致胰岛素抵抗、糖尿病及其心血管并发症。此外，炎症还通过影响癌症和基质细胞的生长、凋亡和增殖而与几种类型的癌症相关。以往的研究认为代谢综合征可能在某些肿瘤的发生、发展和预后不良中起重要作用。目前，代谢综合征和癌症之间的因果关系是更普遍的认识;然而，介导这种关系的确切机制仍然知之甚少。很明显，与代谢综合征相关的炎症状态有助于癌症的发展和进展。明确代谢综合征与癌症之间的联系、炎症在这些疾病中的作用以及寻找新的治疗靶点具有重要意义。本期特刊将提供原创研究论文和综述文章，以推动对代谢综合征相关癌症的机制、产生和管理的理解。在本期特刊中，广泛讨论了代谢综合征与癌症之间的联系。癌症和糖尿病都与乳酸代谢异常有关，高乳酸水平是这些疾病的重要生物学特征。另一方面，高乳酸导致更高的胰岛素抵抗状态和癌细胞的更恶性表型，有利于糖尿病和癌症的发展。考虑到糖尿病和癌症之间的相互作用关系，高乳酸产生在糖尿病和癌症相互作用中的作用不应被忽视。了解糖尿病和癌症相关信号的代谢重塑的分子机制将为糖尿病和癌症治疗提供新的预防和治疗方法。此外，S. Harlid等人研究了人类受试者中代谢综合征与结直肠癌风险之间的关联。在178种炎症和癌症生物标志物中，有12种蛋白质与代谢综合征和/或其组分相关。FGF 21是12种蛋白质之一，也与结直肠癌风险增加有关，这说明了代谢综合征与癌症之间的密切关系。
The inflammatory condition associated with overweight/obesity represents a triggering factor in the pathogenesis of the metabolic syndrome and primarily contributes to the related pathological outcomes. Stimuli including overnutrition, physical inactivity, and ageing might lead to oversecretion of proinflammatory cytokine, ultimately resulting in insulin resistance, diabetes, and its cardiovascular complications. Furthermore, inflammation has also been associated with several types of cancers by influencing growth, apoptosis, and proliferation of cancer and stromal cells. Previous studies propose that the metabolic syndrome may play an imperative role in the initiation, progression, and poor prognosis of some tumors. Currently, the causal association between the metabolic syndrome and cancer is more commonly recognized; nevertheless, the precise mechanisms mediating this relationship remain poorly understood. It has become evident that the inflammatory condition associated with metabolic syndrome contributes to the development and progression of cancer. Ascertaining the link between the metabolic syndrome and cancer, the role of inflammation in these diseases and identification of new therapeutic targets are of great significance. This special issue contributes original research papers and review articles that motivate the continuous efforts to comprehend the mechanisms, production, and management related to cancers associated with the metabolic syndrome.In this special issue, the link between the metabolic syndrome and cancer was extensively discussed. Both cancer and diabetes are associated with abnormal lactate metabolism, and high lactate level is the crucial biological feature of these diseases. On the other hand, high lactate results in a higher insulin-resistant status and a more malignant phenotype of cancer cells, favoring diabetes and cancer development. Considering an interactive relationship between diabetes and cancers, the role of high lactate production in diabetes and cancer interaction should not be neglected. Understanding the molecular mechanisms underlying metabolic remodeling of diabetes-and cancer-related signaling would provide novel preventive and therapeutic approaches for diabetes and cancer treatment. In addition, S. Harlid et al. interrogated the association between the metabolic syndrome and colorectal cancer risk in human subjects. Out of 178 inflammatory and cancer biomarkers, 12 proteins were associated with the metabolic syndrome and/or its components. FGF21, one of the 12 proteins, was also associated with an increased risk for colorectal cancer, exemplifying the intimate relationship between the metabolic syndrome and cancer.