Comparison of hyperthermic hyperpnea elicited during rest and submaximal, moderate-intensity exercise
Comparison of hyperthermic hyperpnea elicited during rest and submaximal, moderate-intensity exercise
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DOI：
10.1152/japplphysiol.00146.2007
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发表时间：
2008-04-01
影响因子：
3.3
通讯作者：
Nishiyasu, Takeshi
中科院分区：
文献类型：
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作者：
Fujii, Naoto;Honda, Yasushi;Nishiyasu, Takeshi
我们测试了这一假设，即在人类中，在休息时引起的高热呼吸过度不同于在次最大，中等强度的运动中引起的。在休息试验中，热水腿浸泡和水灌注服被用来增加食管温度（T-es）在19名健康男性受试者;在运动试验中，T-es增加延长次最大循环[50%峰值O-2摄取（V）超过点O-2）]在热（35摄氏度）。将分钟通气量（（V）/点E）、（V）/点O-2的呼吸当量（（V）/点E/（V）/点O-2）和CO2输出量（（V）/点E/（V）/点O-2）、潮气量（VT）和呼吸频率（f）作为T-es的函数绘制成图。在运动试验中，所有受试者的（V）随T-es的增加（从37.0 ℃至38.7 ℃）而线性增加;在休息试验中，19名受试者中有14名显示呼吸过度的T-es阈值（37.8 ± 0.5 ℃）。在呼吸过度阈值以上，与点E和T-es相关的回归线（V）的斜率在其余试验中显著大于运动试验。此外，与点E/点O-2相关的（V）/点E/点CO 2相关的（V）/点CO 2相关的（V）回归线的斜率，以及T-es的斜率，对于其他人来说都显著大于运动试验。（V）在E点上的增加反映了静息试验中VT和f的增加，但在运动试验中仅反映了f的增加，这是由于VT引起的通气量最初增加之后。最后，与运动试验相比，其余试验中与T-es和VT或f相关的回归线斜率显著更大。这些研究结果表明，高温呼吸确实不同，这取决于一个人是在休息还是在次最大，中等强度的运动。
We tested the hypothesis that, in humans, hyperthermic hyperpnea elicited in resting subjects differs from that elicited during submaximal, moderate-intensity exercise. In the rest trial, hot-water legs-only immersion and a waterperfused suit were used to increase esophageal temperature (T-es) in 19 healthy male subjects; in the exercise trial, T-es was increased by prolonged submaximal cycling [50% peak O-2 uptake ((V) over dot O-2)] in the heat (35 degrees C). Minute ventilation ((V) over dot E), ventilatory equivalent for (V) over dot O-2 ((V) over dot E/(V) over dot O-2) and CO2 output ((V) over dot E/(V) over dot O-2), tidal volume (VT), and respiratory frequency (f) were plotted as functions of T-es. In the exercise trial, (V) over dot E increased linearly with increases (from 37.0 to 38.7 degrees C) in T-es in all subjects; in the rest trial, 14 of the 19 subjects showed a T-es threshold for hyperpnea (37.8 +/- 0.5 degrees C). Above the threshold for hyperpnea, the slope of the regression line relating (V) over dot E and T-es was significantly greater for the rest than the exercise trial. Moreover, the slopes of the regression lines relating (V) over dot E/(V) over dot O-2, (V) over dot E/(V) over dot CO2, and T-es were significantly greater for the rest than the exercise trial. The increase in (V) over dot E reflected increases in VT and f in the rest trial, but only f in the exercise trial, after an initial increase in ventilation due to VT. Finally, the slope of the regression line relating T-es and VT or f was significantly greater for the rest than the exercise trial. These findings indicate that hyperthermic hyperpnea does indeed differ, depending on whether one is at rest or exercising at submaximal, moderate intensity.