Serial change of perivascular fat attenuation index after statin treatment: Insights from a coronary CT angiography follow-up study
Serial change of perivascular fat attenuation index after statin treatment: Insights from a coronary CT angiography follow-up study
复制标题
他汀类药物治疗后血管周围脂肪衰减指数的连续变化：冠状动脉 CT 血管造影随访研究的见解。
DOI：
10.1016/j.ijcard.2020.06.008
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发表时间：
2020-11-15
影响因子：
3.5
通讯作者：
Zhang, Jiayin
中科院分区：
文献类型：
--
作者：
Dai, Xu;Yu, Lihua;Zhang, Jiayin
Background: Perivascular fat attenuation index (FAI) was thought to be an indicator of active vessel inflammation surrounding coronary plaques. However, whether this index can be reduced by statin treatment remains unknown. We aimed to investigate the serial change of lesion-specific perivascular FAI as quantified by coronary computed tomography (CCTA) after statin treatment.Methods: Consecutive patients with chest pain and intermediate likelihood of coronary artery disease were referred for baseline CCTA. Patients were retrospectively included if they were treated medically and underwent follow-up CCTA at 1-year to 1.5-year interval. Lesion-specific perivascular FAI, as well as other plaque features, were measured at baseline and follow-up.Results: One hundred and eight patients (mean age 67.7 +/- 11.1, 76 males) were included. A significant reduction of the FAI value was found for non-calcified plaques and mixed plaques (-68.0 HU +/- 8.5 HU Vs. -71.5 HU +/- 8.1 HU, p < .001 and - 70.5 HU +/- 8.9 HU Vs. -72.8 HU +/- 9.0 HU, p = .014). However, this improvement was not observed for calcified plaques (-70.6 HU +/- 9.7 HU Vs. -71.7 HU +/- 9.9 HU, p = .258). For non-calcified and mixed plaques, the volumes of non-calcified as well as low attenuation component was significantly reduced whereas total plaque volume and volume of calcified component increased. For calcified plaque, total plaque volume also demonstrated remarkable increase after statin treatmentConclusions: Lesion-specific perivascular FAI decreased at mid-term follow-up after statin treatment for non-calcified and mixed plaques. Perivascular FAI can be a potential imaging biomarker to monitor the anti-inflammation response to statin treatments. (C) 2020 Elsevier B.V. All rights reserved.
