Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury
Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury
复制标题
DOI：
10.1016/j.apmr.2007.09.046
复制
发表时间：
2008-04-01
影响因子：
4.3
通讯作者：
Garshick, Eric
中科院分区：
文献类型：
--
作者：
Morse, Leslie R.;Stolzmann, Kelly;Garshick, Eric
目的：评估慢性脊髓损伤（SCI）患者全身炎症的临床决定因素。设计：横断面调查。设置：退伍军人事务部医疗中心。参与者：作为评估SCI相关健康状况的流行病学研究的一部分，63名慢性SCI患者提供了血液样本和有关运动模式和个人习惯的信息。干预措施：不适用。主要结果测量：结果：平均+/-标准差年龄为56 +/-14岁，受试者在受伤后21 +/-13岁进行评估。调整心脏病。高血压和体重指数（BMI），12名机动轮椅使用者的平均CRP（5.11 mg/L）并不显著高于23名使用手动轮椅的参与者（2.19毫克/升）（P= 0.085），但显著高于17名使用辅助设备行走的人（1.41mg）（P= 0.005）和12名独立行走者（1.63mg/L）（P= 0.027）。CRP在肥胖患者中显著升高，但与年龄、吸烟或SCI水平和严重程度无关。CRP升高的参与者报告尿路感染（UTI）或压力性溃疡在一年内，但调整这并没有占CRP升高机动轮椅users.Conclusions：这些结果表明，CRP在慢性SCI是独立相关的机车模式，BMI，和历史的压力性溃疡和UTI。这表明，未来的研究在SCI调查是否修改这些因素影响全身炎症和心血管健康。
Objective: To assess clinical determinants of systemic inflammation in persons with chronic spinal cord injury (SCI).Design: Cross-sectional survey.Setting: Veterans Affairs medical center.Participants: As part of an epidemiologic study assessing SCI-related health conditions, 63 men with chronic SCI provided a blood sample and information regarding locomotive mode and personal habits.Interventions: Not applicable.Main Outcome Measure: Plasma high-sensitivity C-reactive protein (CRP).Results: The mean +/- standard deviation age was 56 +/- 14y and participants were assessed 21 +/- 13y after injury. Adjusting for heart disease. hypertension, and body mass index (BMI), the mean CRP in 12 motorized wheelchair users (5.11 mg/L) was not Significantly greater than 23 participants who used a manual wheelchair (2.19mg/L) (P=.085) but was significantly greater than the 17 who walked with an assistive device (1.41mg) (P=.005) and the 12 who walked independently (1.63mg/L) (P=.027). CRP was significantly greater in participants with obesity but was not related to age, smoking, or SCI level and severity. CRP was elevated in participants reporting a urinary tract infection (UTI) or pressure ulcer within a year, but adjustment for this did not account for the elevated CRP in motorized wheelchair users.Conclusions: These results suggest that CRP in chronic SCI is independently related to locomotive mode, BMI, and a history of pressure ulcers and UTI. It is suggested that future studies in SCI investigate whether modifying these factors influence systemic inflammation and cardiovascular health.