Population genetics for Y-chromosomal STRs haplotypes of Chinese Xibe ethnic group.
Population genetics for Y-chromosomal STRs haplotypes of Chinese Xibe ethnic group.
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DOI：
10.1016/j.fsigen.2010.08.004
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
M. Shi;R. Bai;Lu Bai;Xiao-jun Yu
中科院分区：
文献类型：
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作者：
M. Shi;R. Bai;Lu Bai;Xiao-jun Yu
对居住在辽宁(中国东北)的280名健康锡伯族男性个体的11个Y染色体短串联重复序列(STR)进行了等位基因频率和单倍型频率的检测。Y-STRS基因座的基因多样性范围为0.3618(DYS391)~0.9686(DYS385a/b)。在Y-STR基因座上共检测到237个单倍型，其中207个为独有，2个个体有22个，3个个体共有4个，4个个体共有3个，5个个体共有1个。观察到的单倍型多样性为0.9984，识别能力为0.8464。单因素方差分析显示锡伯族人与来自中国等亚洲群体的16个参考群体之间存在显著的遗传异质性，证明了建立中国锡伯族地方数据库用于法医应用的合理性。
Allele and haplotype frequencies of 11 Y-chromosomal short tandem repeats (STRs) included in the PowerPlex®Y Systems (Promega) were determined in a sample of 280 unrelated healthy autochthonous male individuals of the Chinese Xibe ethnic minority group living in Liaoning (northeast of China). The gene diversity values of the Y-STRs loci ranged from 0.3618 (DYS391) to 0.9686 (DYS385a/b). A total of 237 haplotypes were identified in the Y-STR loci, among which 207 were unique, 22 was found in 2 individuals, 4 were shared in 3 individuals, 3 were shared in 4 individuals, and 1 was shared in 5 individuals. The observed haplotype diversity value and discrimination capacity were 0.9984 and 0.8464, respectively. AMOVA tests demonstrated significant genetic heterogeneity between the Xibes and 16 reference populations from China and other Asian populations, justifying the establishment of local databases in the Chinese Xibe ethnic group for forensic application.