Importance of airway blood flow on particle clearance from the lung.
Importance of airway blood flow on particle clearance from the lung.
复制标题
气道血流对肺部颗粒清除的重要性。
DOI：
10.1152/jappl.1996.81.5.1878
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Foster,WM
中科院分区：
文献类型：
--
作者：
Wagner,EM;Foster,WM
瓦格纳 (Elizabeth M.) 和 W. 迈克尔·福斯特 (W. Michael Foster)。气道血流对肺部颗粒清除的重要性。应用。 Physiol.81(5): 1878–1883, 1996.—气道循环在支持粘液纤毛功能中的作用基本上尚未被研究。我们评估了麻醉通气羊（n = 8）中惰性、不溶性颗粒的气道清除情况，其中支气管灌注受到控制，以确定气道粘膜血流是否对于维持颗粒通过气道的表面运输至关重要。将支气管食管动脉的支气管分支插管并以控制流量（0.6 ml·min−1·kg−1）灌注自体血液或停止灌注。使羊处于仰卧位，并在稳态133Xe通气扫描后指定感兴趣的肺部区域，惰性99mTc标记的硫胶体气溶胶（直径2.1微米）沉积在肺部。根据右肺区和左肺区获得的活动时间数据确定放射性标记颗粒的清除动力学。气溶胶沉积后 60 分钟，控制支气管血流条件下的平均气道颗粒滞留率为右肺区 57 ± 7 (SE)%，左肺区为 53 ± 8%。当支气管血流停止时，颗粒清除率显着受损，例如，60 分钟时右肺区和左肺区平均分别为 77 ± 6 和 76 ± 7%（P < 0.05）。这些数据表明支气管循环对不溶性颗粒的粘液纤毛运输有显着影响。可能解释这些结果的潜在机制包括支气管循环对营养物流动的重要性、气道壁温度和湿度的维持以及与组织缺血相关的介质和后遗症的释放。
Wagner, Elizabeth M., and W. Michael Foster.Importance of airway blood flow on particle clearance from the lung.J. Appl. Physiol.81(5): 1878–1883, 1996.—The role of the airway circulation in supporting mucociliary function has been essentially unstudied. We evaluated the airway clearance of inert, insoluble particles in anesthetized ventilated sheep (n= 8), in which bronchial perfusion was controlled, to determine whether airway mucosal blood flow is essential for maintaining surface transport of particles through airways. The bronchial branch of the bronchoesophageal artery was cannulated and perfused with autologous blood at control flow (0.6 ml ⋅ min−1⋅ kg−1) or perfusion was stopped. With the sheep in a supine position and after a steady-state133Xe ventilation scan for designation of lung zones of interest, an inert99mTc-labeled sulfur colloid aerosol (2.1-μm diameter) was deposited in the lung. The clearance kinetics of the radiolabeled particles were determined from the activity-time data obtained for right and left lung zones. At 60 min postdeposition of aerosol, average airway particle retention for control bronchial blood flow conditions was 57 ± 7 (SE)% for the right and 53 ± 8% for the left lung zones. Clearance of particles was significantly impaired when bronchial blood flow was stopped, e.g., right and left lung zones averaged 77 ± 6 and 76 ± 7% at 60 min, respectively (P< 0.05). These data demonstrate a significant influence of the bronchial circulation on mucociliary transport of insoluble particles. Potential mechanisms that may account for these results include the importance of the bronchial circulation for nutrient flow, maintenance of airway wall temperature and humidity, and release of mediators and sequelae associated with tissue ischemia.