DEVELOPMENT AFTER EXPOSURE TO POLYCHLORINATED-BIPHENYLS AND DICHLORODIPHENYL DICHLOROETHENE TRANSPLACENTALLY AND THROUGH HUMAN-MILK
DEVELOPMENT AFTER EXPOSURE TO POLYCHLORINATED-BIPHENYLS AND DICHLORODIPHENYL DICHLOROETHENE TRANSPLACENTALLY AND THROUGH HUMAN-MILK
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DOI：
10.1016/s0022-3476(88)80569-9
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发表时间：
1988-12-01
影响因子：
5.1
通讯作者：
TULLY, M
中科院分区：
文献类型：
--
作者：
GLADEN, BC;ROGAN, WJ;TULLY, M
目的：确定经胎盘或通过母乳喂养暴露于多氯联苯（PCBs）或二氯二苯二氯乙烯（DDE）是否会影响6或12个月大婴儿发育的Baylet量表评分。设计：队列研究从出生到1岁。设置：一般社区。参与者：858名婴儿的志愿者样本，其中802名婴儿在6个月或12个月或两者时都有Bayley评分。干预措施：无。测量和主要结果：Bayley量表和化学测量独立进行。较高的经胎盘暴露于多氯联苯与较低的心理评分在6个月和12个月的年龄，最低和最高的PCB组之间的平均分数的差异是7分，在6个月和8分，在12个月。更高的DDE经胎盘暴露与6个月大时更高的心理评分相关（最低和最高DDE组的平均评分之间的差异为6分），但在12个月大时没有发现相关性。通过母乳喂养接触任何一种化学物质显然与贝利评分无关。结论：经胎盘暴露于多氯联苯与较低的心理评分相关。母乳喂养没有产生有害影响。
Objective: To determine whether exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE), either transplacentally or through breast feeding, affected scores on the Baylet Scales of Infant Development at 6 or 12 months of age. Design: Cohort followed from birth to 1 year of age. Setting: General community. Participants: Volunteer sample of 858 infants, of whom 802 had Bayley scores available at either 6 months or 12 months or both. Interventions: None. Measurements and main results: Bayley scales and chemical measurements were done independently. Higher transplacental exposure to PCBs was associated with lower psychomotor scores at both 6 and 12 months of age; the difference between the mean scores in the lowest and highest PCB groups was 7 points at 6 months and 8 points at 12 months. Higher transplancental exposure to DDE was associated with higher mental scores at 6 months of age (the difference between the mean scores in the lowest and highest DDE groups was 6 points), but no relationship was seen at 12 months. Exposure to either chemical through breast feeding was apparently unrelated to Bayley scores. Conclusions: Transplacental exposure to PCBs was associated with lower psychomotor scores. No deleterious effects were associated with breast feeding.