Breast-feeding among women exposed to polybrominated biphenyls in Michigan.
Breast-feeding among women exposed to polybrominated biphenyls in Michigan.
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DOI：
10.1289/ehp.01109133
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发表时间：
2001-11
影响因子：
10.4
通讯作者：
Rubin C
中科院分区：
文献类型：
--
作者：
Thomas AR;Marcus M;Zhang RH;Blanck HM;Tolbert PE;Hertzberg V;Henderson AK;Rubin C
20世纪70年代初，美国最大的工业事故导致密歇根州食品供应被多溴联苯(PBBS)广泛污染。多溴联苯与被认为是内分泌干扰物的化合物在化学上的相似性引发了多溴联苯是否会影响生殖系统的问题。在目前的分析中，我们检查了血清中多溴联苯的测量与哺乳频率和持续时间之间的关系。居住在暴露于多溴联苯的农场或从农场获得食物的人在密歇根州公共卫生部的登记中登记。队列中的女性成员被邀请参加一项关于生殖结果的电话调查。本分析涉及的三个结果是：a)决定母乳喂养(是/否)；b)母乳喂养作为主要营养来源的持续时间(以月为单位)；c)母乳喂养的总持续时间(以月为单位)。即使在控制了母亲年龄、既往母乳喂养史、体重指数、母亲教育、家庭收入、怀孕前一年吸烟史、怀孕前三个月的饮酒史、甲状腺疾病史、婴儿的孕周、怀孕时间和出生年份后，这三种结果都与血清PBB水平没有显著相关性。
In the early 1970s, the largest industrial accident in the United States resulted in widespread contamination of the food supply in Michigan with polybrominated biphenyls (PBBs). The chemical similarity of PBBs to compounds implicated as endocrine disruptors has raised the question of whether PBBs could affect the reproductive system. In the present analysis we examine the relation between serum measurements of PBBs and the frequency and duration of lactation. Persons who lived on or received food from farms exposed to PBBs were enrolled in a registry by the Michigan Department of Public Health. Female members of the cohort were invited to participate in a telephone survey of reproductive outcomes. The three outcomes of interest in the present analysis were a) the decision to breast-feed (yes/no); b) the duration, in months, of breast-feeding as the main source of nutrition; and c) the total duration, in months, of breast-feeding. None of the three outcomes was significantly associated with serum PBB levels, even after controlling for maternal age, previous history of breast-feeding, body mass index, maternal education, household income, history of smoking in the year before pregnancy, consumption of alcohol during the first trimester of pregnancy, history of thyroid disorder, gestational age of the infant in weeks, time to pregnancy, and year of birth.