New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology.
New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology.
复制标题
从分子生物物理学到微生物生态学对霍乱弧菌生物膜的新见解。
DOI：
10.1007/978-3-031-22997-8_2
复制
发表时间：
2023
影响因子：
--
通讯作者：
Waters,ChristopherM
中科院分区：
文献类型：
--
作者：
Tai,Jung-ShenB;Ferrell,MicahJ;Yan,Jing;Waters,ChristopherM
孟加拉国农村地区48%的霍乱感染可以通过简单过滤未经净化的水和检测霍乱患者粪便中的霍乱弧菌聚集物来预防，这是实现的。霍乱生物膜在霍乱发病机制中起着核心作用。我们目前处于第七次霍乱大流行，由1961年开始的El Tor生物型菌株的O1血清型引起。据估计，V。霍乱每年导致数百万人感染，超过10万人死亡。鉴于霍乱持续出现在无法获得清洁水的地区，例如2010年地震后的海地或也门内战，加强我们对霍乱疾病的了解仍然是世界公共卫生的优先事项。随着世界受到新冠肺炎大流行的影响，霍乱的监测和治疗也受到影响，这在非洲引起了重大关切。除了生物膜形成在其生命周期中的重要性外，霍乱弧菌已经成为了解调节生物膜形成的细菌信号转导网络和发现细菌表面附着和生物膜成熟的基本原理的关键模型系统。本章将重点介绍对V的最新见解。霍乱菌生物膜包括它们的结构，在环境生存和感染中的生态作用，控制它们的调控系统，以及对V的本质的生物力学见解。霍乱菌生物膜。
With the discovery that 48% of cholera infections in rural Bangladesh villages could be prevented by simple filtration of unpurified waters and the detection ofVibrio choleraeaggregates in stools from cholera patients it was realizedV. choleraebiofilms had a central function in cholera pathogenesis. We are currently in the seventh cholera pandemic, caused by O1 serotypes of the El Tor biotypes strains, which initiated in 1961. It is estimated thatV. choleraeannually causes millions of infections and over 100,000 deaths. Given the continued emergence of cholera in areas that lack access to clean water, such as Haiti after the 2010 earthquake or the ongoing Yemen civil war, increasing our understanding of cholera disease remains a worldwide public health priority. The surveillance and treatment of cholera is also affected as the world is impacted by the COVID-19 pandemic, raising significant concerns in Africa. In addition to the importance of biofilm formation in its life cycle, V. choleraehas become a key model system for understanding bacterial signal transduction networks that regulate biofilm formation and discovering fundamental principles about bacterial surface attachment and biofilm maturation. This chapter will highlight recent insights intoV. choleraebiofilms including their structure, ecological role in environmental survival and infection, regulatory systems that control them, and biomechanical insights into the nature ofV. choleraebiofilms.