The role of mosquito olfaction in oviposition site location and in the avoidance of unsuitable hosts.
The role of mosquito olfaction in oviposition site location and in the avoidance of unsuitable hosts.
复制标题
蚊子嗅觉在产卵地点定位和避免不合适宿主中的作用。
DOI：
--
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Christine Woodcock
中科院分区：
文献类型：
--
作者：
J. Pickett;Christine Woodcock
在与不同团体的合作研究中，从蚊子信息素的首次识别到非宿主回避的讨论，追踪了蚊子嗅觉利用的发展。库蚊属蚊子产卵信息素的特征，例如库蚊。致倦库蚊作为一种新型手性内酯，为许多复杂的不对称合成和经济的大规模外消旋产品路线提供了动力。后者为三大洲成功的现场试验提供了材料。在这项实地工作过程中，我们获得了证据，表明直接源自产卵位点的化学信息素对于产卵信息素的活性至关重要。最近的研究正在阐明这些药物的性质及其地理变异性。最初，我们使用合成的产卵信息素将蚊子吸引到经过生物合理杀幼虫剂处理的地点。然而，可回收的生物防治剂为资源贫乏地区提供了更好的前景。已经设计了一种信息素生产的生物技术方法，涉及通过培养高等植物来产生廉价的起始材料。对以农场动物为食的双翅类害虫的新研究表明，存在一种基于化学信息的机制，通过该机制可以避免宿主物种内不合适的个体。似乎存在一个类似的过程，蚊子会避开某些潜在的人类宿主，一旦信息化学/嗅觉相互作用得到充分阐明，就会提高开发新型、合理识别的驱虫剂的前景。
Developments in the exploitation of mosquito olfaction are traced, in collaborative studies with various groups, from the first identification of a mosquito pheromone through to a discussion of non-host avoidance. The characterization of the oviposition pheromone for mosquitoes in the genus Culex, e.g. Culex quinquefasciatus, as a novel chiral lactone ester provided the impetus for a number of sophisticated asymmetric syntheses and economical large-scale routes to racemic products. The latter have provided material for successful field trials in three continents. During the course of this field work, we obtained evidence that semiochemicals originating directly from the oviposition site are essential for activity of the oviposition pheromone. Recent studies are elucidating the nature of these agents and their geographical variability. Initially, we used synthetic oviposition pheromone to attract mosquitoes to sites treated with a biorational larvicide. However, recyclable biological control agents offer better prospects for resource-poor regions. A biotechnological approach to pheromone production has been devised involving the generation of inexpensive starting materials by the cultivation of a higher plant. New studies on dipterous pests feeding on farm animals indicate a semiochemically based mechanism by which unsuitable individuals within the host species are avoided. There appears to be an analogous process in which mosquitoes avoid certain potential human hosts, thereby raising prospects for the development of novel, rationally identified repellents once the semiochemical/olfactory interactions have been fully elucidated.