Carbon-carbon bond cleavage by cytochrome P450BioI (CYP107H1)
Carbon-carbon bond cleavage by cytochrome P450BioI (CYP107H1)
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DOI：
10.1039/b311652b
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发表时间：
2004-01-07
影响因子：
4.9
通讯作者：
De Voss, JJ
中科院分区：
文献类型：
--
作者：
Cryle, MJ;De Voss, JJ
细胞色素P450（Biol）（CYP107 H1）被认为是枯草芽孢杆菌生物素生物合成的庚二酸等价物：我们在这里报告，这种多功能P450用于脂肪酸链内裂解的机制途径是通过连续形成醇和苏式二醇中间体，还报告了中间体的可能绝对构型。
Cytochrome P450(Biol) (CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional P450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.