The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition
The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition
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DOI：
10.1016/j.plefa.2007.10.016
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发表时间：
2007-11-01
影响因子：
3
通讯作者：
Diau, Guan-Yeu
中科院分区：
文献类型：
--
作者：
Brenna, J. Thomas;Diau, Guan-Yeu
大量关于围产期长链多不饱和脂肪酸营养的研究阐明了膳食中二十二碳六烯酸(DHA)和花生四烯酸(ARA)对中枢神经系统多不饱和脂肪酸浓度的影响。在人类、杂食性灵长类动物和仔猪中，DHA和ARA的血浆和红细胞浓度随着饮食中预制的DHA和ARA的增加而增加。大脑和视网膜DHA对饮食有反应，而ARA则不是。DHA在细胞和组织中的浓度最高，与高能量消耗有关，与线粒体和突触体内的高DHA水平一致。DHA是二十二烷类化合物的底物，是当前人们非常感兴趣的化合物的信号。氧化代谢率高的组织中的高浓度可能是由与氧化代谢相关的关键作用解释的。(C)2007爱思唯尔有限公司。保留所有权利。
Numerous studies on perinatal long-chain polyunsaturated fatty acid nutrition have clarified the influence of dietary docosahexaenoic acid (DHA) and arachidonic acid (ARA) on central nervous system PUFA concentrations. In humans, omnivorous primates, and piglets, DHA and ARA plasma and red blood cells concentrations rise with dietary preformed DHA and ARA. Brain and retina DHA are responsive to diet while ARA is not. DHA is at highest concentration in cells and tissues associated with high energy consumption, consistent with high DHA levels in mitochondria and synaptosomes. DHA is a substrate for docosanoids, signaling compounds of intense current interest. The high concentration in tissues with high rates of oxidative metabolism may be explained by a critical role related to oxidative metabolism. (C) 2007 Elsevier Ltd. All rights reserved.