Tissue homeostasis and aging: new insight from the fly intestine
Tissue homeostasis and aging: new insight from the fly intestine
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DOI：
10.1016/j.ceb.2017.06.005
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发表时间：
2017-10-01
影响因子：
7.5
通讯作者：
Bardin, Allison J.
中科院分区：
文献类型：
--
作者：
Gervais, Louis;Bardin, Allison J.
成体干细胞在生物体的整个生命过程中促进组织稳态。控制干细胞活性的机制受到严格审查，目的是阐明它们如何介导组织稳态，促进成人组织的年龄相关性衰退，并促进肿瘤发生。最近，使用模型系统，如果蝇肠道丰富了我们的理解，干细胞如何整合局部和全身信号，以维持组织和器官的功能，在生理条件下的稳态或损伤后。在这里，我们强调了在这个模型中取得的最新进展，允许更好地了解干细胞谱系的决定，他们的调节上皮和器官内的线索，以及他们在衰老过程中的活动改变。
Adult somatic stem cells facilitate tissue homeostasis throughout the life of the organism. The mechanisms controlling stem cell activity are under intense scrutiny, with the aims of elucidating how they mediate tissue homeostasis, contribute to age-related decline of adult tissues, and promote tumorigenesis. Recently, the use of model systems such as the Drosophila intestine has enriched our understanding of how stem cells integrate local and systemic signals to maintain tissue and organs function in physiological conditions of homeostasis or after damage. Here we highlight recent advances made in this model allowing a better understanding of stem cell lineage decisions, their regulation by epithelial and intra-organ cues, and their altered activity during aging.