Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance.
Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance.
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DOI：
10.1101/cshperspect.a029280
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发表时间：
2018-09-04
影响因子：
7.2
通讯作者：
Sotomayor M
中科院分区：
文献类型：
--
作者：
Jaiganesh A;Narui Y;Araya-Secchi R;Sotomayor M
钙粘蛋白形成一个大家族的蛋白质经常参与钙依赖性细胞粘附。尽管经典的钙粘蛋白家族成员可以在细胞之间提供物理连接，但一种特殊的钙粘蛋白亚群使用它们的细胞外结构域将单个上皮感觉细胞的顶端特化相互连接。其中两种钙粘蛋白，钙粘蛋白-23 （CDH23）和原钙粘蛋白-15 (PCDH15)，形成细胞外“尖端连接”细丝，连接毛细胞上的立体纤毛的顶端束，这对内耳机械转导至关重要。当这些神经束受到来自声音或头部运动的机械刺激而偏转时，尖端连接起毛细胞机械敏感通道，从而启动感官知觉。在这里，我们回顾了这些尖端连接钙粘蛋白的不同寻常和多样化的结构特性及其与耳聋相关的错义突变的功能意义。基于CDH23和PCDH15的结构特点，我们讨论了在内耳力学转导过程中，钙粘蛋白的纳米力学和毛细胞束的微观力学之间的桥梁的尖端连接的弹性和模型。
Cadherins form a large family of proteins often involved in calcium-dependent cellular adhesion. Although classical members of the family can provide a physical bond between cells, a subset of special cadherins use their extracellular domains to interlink apical specializations of single epithelial sensory cells. Two of these cadherins, cadherin-23 (CDH23) and protocadherin-15 (PCDH15), form extracellular “tip link” filaments that connect apical bundles of stereocilia on hair cells essential for inner-ear mechanotransduction. As these bundles deflect in response to mechanical stimuli from sound or head movements, tip links gate hair-cell mechanosensitive channels to initiate sensory perception. Here, we review the unusual and diverse structural properties of these tip-link cadherins and the functional significance of their deafness-related missense mutations. Based on the structural features of CDH23 and PCDH15, we discuss the elasticity of tip links and models that bridge the gap between the nanomechanics of cadherins and the micromechanics of hair-cell bundles during inner-ear mechanotransduction.
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影响因子：
9.8
作者：
Ahmed, ZM;Riazuddin, S;Wilcox, ER
通讯作者：
Wilcox, ER
影响因子：
16.6
作者：
Araya-Secchi, Raul;Neel, Brandon L.;Sotomayor, Marcos
通讯作者：
Sotomayor, Marcos
影响因子：
3.7
作者：
Abdi, Samia;Bahloul, Amel;Petit, Christine
通讯作者：
Petit, Christine
影响因子：
3.9
作者：
Baux, David;Faugere, Valerie;Roux, Anne-Francoise
通讯作者：
Roux, Anne-Francoise
DOI：
10.1073/pnas.2334417100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Belyantseva, IA;Boger, ET;Friedman, TB
通讯作者：
Friedman, TB