Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells.
Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells.
复制标题
作者：
Kirkham F;Pera A;Simanek AM;Bano A;Morrow G;Reus B;Caserta S;Smith HE;Davies KA;Rajkumar C;Kern F
人类巨细胞病毒(CMV)感染与动脉粥样硬化、更高的心血管疾病(CVD)风险和记忆T细胞(TMEM)增加有关。T细胞也与CVD有关，与CMV感染无关。为了更好地了解巨细胞病毒相关的心血管疾病风险，我们研究了巨细胞病毒(免疫球蛋白)血清状态和中央动脉(颈动脉-股)脉搏波速度(CfPWV)之间的关系，后者是心血管疾病的早期独立预测因子。我们还调查了这种关联是否可能反映在TMEM和/或其他T细胞亚群的分布上。方法：健康老年志愿者(60-93岁)接受常规的临床和实验室评估，包括对符合条件的参与者进行cfPWV评估。用流式细胞仪检测记忆性T细胞、CD28ullT细胞和CMV特异性T细胞的比例。研究了以下相关性：CMV血清状态/cfPWV、CMV血清状态/TMEM比例、TMEM/cfPWV比例、CD28空T细胞/cfPWV和CMV特异性T细胞/cfPWV。线性回归模型被用来根据需要调整年龄、性别、社会经济地位、吸烟、腰臀比、胆固醇和血压。结果：发现有统计学意义的正相关(给出完全校正模型的P值)；男性CMV血清状态/cfPWV(P≤0.0 1)而女性不存在；CMV血清状态/CD4TMEM比例在男性(P≤0.0 5)但在女性中不存在；CD4TMEM/cfPWV在CMV血清阳性(P≤0.0 5)人群中所占比例但不在CMV血清阴性(P结论：CMV感染通过增加cfPWV而增加老年男性心血管疾病的风险。这可能部分是由于CD4TMEM比例的增加，在CMV+的老年人中发现了更多的CD4TMEM，男性比女性更多。鉴于全球巨细胞病毒的高流行率，我们的发现指出了一个重大的全球健康问题。可能需要新的策略来减轻与巨细胞病毒相关的增加的心血管疾病风险。
Human Cytomegalovirus (CMV) infection is associated with atherosclerosis, higher cardiovascular disease (CVD) risk, and an increase in memory T-cells (Tmem). T-cells have also been implicated in CVD, independently of CMV infection. To better understand the CMV-associated CVD risk, we examined the association between CMV (IgG) serostatus and central aortic (carotid-to-femoral) pulse wave velocity (cfPWV), an early, independent predictor of CVD. We also investigated if such an association might be reflected by the distribution of Tmem and/or other T-cell subsets. Methods: Healthy older volunteers (60-93 years) underwent routine clinical and laboratory evaluation, including assessment of cfPWV in eligible participants. Flow-cytometry was used to assess proportions of memory T-cells, CD28null T-cells, and CMV-specific T-cells. The following associations were examined; CMV serostatus/cfPWV, CMV serostatus/proportion of Tmem, proportion of Tmem/cfPWV, CD28null T-cells/cfPWV, and CMV-specific T-cells/cfPWV. Linear regression models were used to adjust for age, sex, socioeconomic status, smoking, waist-to-hip ratio, cholesterol, and blood pressure as required. Results: Statistically significant positive associations were found (P-values for the fully adjusted models are given); CMV serostatus/cfPWV in men (P ≤ 0.01) but not in women, CMV serostatus/proportions of CD4 Tmem in men (P ≤ 0.05) but not in women; proportions of CD4 Tmem/cfPWV among CMV seropositive (CMV+) people (P ≤ 0.05) but not CMV seronegative (CMV-) people. Conclusion: CMV infection increases the CVD risk of older men by increasing cfPWV. This may be mediated in part by increased proportions of CD4 Tmem, higher numbers of which are found in CMV+ older people and more so among men than women. Given the high prevalence of CMV worldwide, our findings point to a significant global health issue. Novel strategies to mitigate the increased CVD risk associated with CMV may be required.