Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3'-untranslated region of the prothrombin gene
Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3'-untranslated region of the prothrombin gene
复制标题
DOI：
10.1046/j.1365-2141.1997.3093130.x
复制
发表时间：
1997-09-01
影响因子：
6.5
通讯作者：
Baglin, T
中科院分区：
文献类型：
--
作者：
Brown, K;Luddington, R;Baglin, T
504例静脉血栓栓塞患者与对照组相比，FII 20210G/A突变的优势比为2.0 (95% Cl 1.0-4.0)，因子V Leiden的优势比为5.8 （95% CI 3.3-10.3）。3/504例患者两种突变均为杂合，无一例合并天然抗凝血药物缺乏和FII 20210G/A突变。我们得出结论，FII 20210G/A突变存在于2.6%的人群中，携带者发生静脉血栓栓塞的相对风险为2.0。
The odds ratio for the FII 20210G/A mutation in 504 patients with venous thromboembolism compared to controls was 2.0 (95% Cl 1.0-4.0) and, for factor V Leiden, 5.8 (95% CI 3.3-10.3). 3/504 patients were heterozygous for both mutations, None of the patients had combined natural anticoagulant deficiency and the FII 20210G/A mutation. We conclude that the FII 20210G/A mutation is present in 2.6% of the population and the relative risk of venous thromboembolism in carriers is 2.0.