The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target
The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target
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DOI：
10.1038/cgt.2011.5
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发表时间：
2011-06-01
影响因子：
6.4
通讯作者：
Hui, K. M.
中科院分区：
文献类型：
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作者：
Ong, H. T.;Tan, P. K.;Hui, K. M.
血管浸润是与肝细胞癌（HCC）早期复发相关的临床病理特征之一。在这项研究中，我们采用高密度的Affyphase寡核苷酸基因芯片（Affyphase，Santa Clara，CA）来比较有和没有血管浸润的HCC的表达谱。建立的基因表达数据库的数据挖掘显示，白细胞来源的趋化因子-2（LECT 2）的转录下调的HCC患者血管浸润。LECT 2在人HCC活检组织中的表达显著降低（P
Vascular invasion is one of the clinicopathologic features that are associated with early recurrence of human hepatocellular carcinoma (HCC). In this study, we have employed high-density Affymetrix oligonucleotide GeneChips (Affymetrix, Santa Clara, CA) to compare the expression profiles of HCC with and without vascular invasion. Data mining of the gene expression database established revealed that leukocyte cell-derived chemotaxin-2 (LECT2) transcripts were downregulated in HCC patients with vascular invasion. Expression of LECT2 in human HCC biopsies was significantly reduced (P