Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii
Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii
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徐长卿根皮中苯乙酮的潜在降血糖作用。
DOI：
10.1080/14786419.2018.1443100
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发表时间：
2019-08-18
影响因子：
2.2
通讯作者：
Li, Jin-Long
中科院分区：
文献类型：
--
作者：
Jiang, Hao-Wen;Gu, Shan-Shan;Li, Jin-Long
从Cynanchum wilfordii （Maxim.）的根皮中分离到三个新的苯乙酮，命名为cywilforones A- c（1-3）和cynandione A(4)。Hemsl。通过光谱分析和化学方法推导了它们的结构。化合物1和4通过下调磷酸烯醇丙酮酸羧激酶和葡萄糖-6-磷酸酶的表达抑制肝脏糖异生，表现出潜在的降糖作用。这是首次报道从雷公藤根皮中提取的苯乙酮类化合物在体外具有潜在的降血糖活性。
Three new acetophenones, named cynwilforones A-C (1-3), together with cynandione A (4) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds 1 and 4 exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of C. wilfordii possesses potential hypoglycemic activity in vitro.[GRAPHICS].