Content-specific activation during associative long-term memory retrieval
Content-specific activation during associative long-term memory retrieval
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DOI：
10.1016/j.neuroimage.2005.05.006
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发表时间：
2005-10-01
期刊：
影响因子：
5.7
通讯作者：
Rösler, F
中科院分区：
文献类型：
--
作者：
Khader, P;Burke, M;Rösler, F
我们测试了被认为在感知过程中在不同的大脑皮层网络中处理的视觉刺激材料(即面孔和空间位置)在长期记忆回忆过程中是否也在地形图上是分离的。通过广泛的过度学习程序，12名参与者学习了词和面孔、词和空间位置的配对联系。每个单词都被组合成一个或两个位置或一个或两个脸。几天后，在线索回忆测试中记录了功能磁共振成像，在这项测试中，呈现了两个单词，参与者必须决定这两个单词是否通过一个共同的中介，即面孔或位置相互联系。这一范式加强了从长期记忆中提取，而不会混淆回忆和知觉过程。研究发现，在位置和面孔的回忆过程中，大脑皮质区域的网络被不同地激活，包括沿背侧和腹侧视觉通路的区域，例如对于位置的顶叶和中央前皮质，以及对于面孔的左侧前额叶、颞叶(包括梭形回)和后扣带回。在这些区域的一个子集中，大胆的反应被发现随着需要重新激活的关联数量的增加而单调增加。这些结果表明，在长期记忆提取过程中，材料特定的皮质网络被系统性地激活，这些区域与知觉记忆和工作记忆任务中的位置和面孔也激活的区域重叠。(C)2005 Elsevier Inc.保留所有权利。
We tested whether visual stimulus material that is assumed to be processed in different cortical networks during perception (i.e., faces and spatial positions) is also topographically dissociable during long-term memory recall. With an extensive overlearning procedure, 12 participants learned paired associates of words and faces and words and spatial positions. Each word was combined with either one or two positions or one or two faces. fMRI was recorded several days later during a cued recall test, in which two words were presented and the participants had to decide whether these were linked to each other via a common mediator, i.e., a face or a position. This paradigm enforces retrieval from long-term memory without confounding recall with perceptual processes. A network of cortical areas was found to be differently activated during recall of positions and faces, including regions along the dorsal and ventral visual pathways, such as the parietal and precentral cortex for positions and the left prefrontal, temporal (including fusiform gyrus) and posterior cingulate cortex for faces. In a subset of these areas, the BOLD response was found to increase monotonically with the number of the to-be-re-activated associations.. These results show that material-specific cortical networks are systematically activated during long-term memory retrieval that overlap with areas also activated by positions and faces during perceptual and working memory tasks. (C) 2005 Elsevier Inc. All rights reserved.