Endorphins and the control of breathing. Ability of naloxone to restore flow-resistive load compensation in chronic obstructive pulmonary disease.
Endorphins and the control of breathing. Ability of naloxone to restore flow-resistive load compensation in chronic obstructive pulmonary disease.
复制标题
内啡肽和呼吸的控制。
DOI：
10.1056/nejm198105143042002
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Edelman,NH
中科院分区：
文献类型：
--
作者：
Santiago,TV;Remolina,C;Scoles3rd,V;Edelman,NH
由于麻醉药物会严重抑制呼吸，我们测试了内源性阿片类药物是否影响慢性阻塞性肺疾病（COPD）的呼吸控制，推断慢性呼吸困难的压力可能会导致“内啡肽”的产生。在 14 名 COPD 患者（但没有呼吸衰竭）和 8 名正常对照中，我们测量了通气量、机械肺功能、对二氧化碳的呼吸敏感性，以及呼吸阻力增加引起的呼吸努力的增加；每次测量均在阿片拮抗剂纳洛酮给药之前和之后进行。在使用纳洛酮之前，呼吸阻力的增加增强了所有对照组的呼吸努力，但 14 名慢性阻塞性肺病患者中有 7 名没有反应。使用纳洛酮后，这七名患者出现了负荷反应。此外，在给有反应的患者服用药物后，由阻力引起的呼吸努力也增加了。这些数据表明内啡肽的精制可以最大限度地减少慢性气道阻塞的压力。 （新英格兰医学杂志，1981 年；304：1190–5。）
Since narcotic drugs profoundly depress breathing, we tested whether endogenous opioids influenced control of breathing in chronic obstructive pulmonary disease (COPD), reasoning that the stress of chronic dyspnea might cause elaboration of "endorphins." In 14 patients with COPD (but without respiratory failure) and eight normal controls, we measured ventilation, mechanical lung function, respiratory sensitivity to carbon dioxide, and the increase in respiratory effort elicited by an increase in resistance to breathing; each measurement was performed before and after administration of the opiate antagonist naloxone. Before naloxone, increased resistance to breathing enhanced respiratory effort in all controls, but seven of 14 patients with COPD had no response. After naloxone, these seven patients had load responses. Furthermore, the respiratory effort elicited by the resistance also increased after the drug was given to the patients who had had a response. These data suggest that endorphin elaboration minimizes the stress of chronic airway obstruction. (N Engl J Med. 1981; 304:1190–5.)