Plasma irisin levels are associated with hemodynamic and clinical outcome in idiopathic pulmonary arterial hypertension patients
Plasma irisin levels are associated with hemodynamic and clinical outcome in idiopathic pulmonary arterial hypertension patients
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血浆鸢尾素水平与特发性肺动脉高压患者的血流动力学和临床结果相关
DOI：
10.1007/s11739-020-02467-0
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发表时间：
2020-08-14
影响因子：
4.6
通讯作者：
Wu, Bingxiang
中科院分区：
文献类型：
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作者：
Sun, Na;Chen, Yiqiang;Wu, Bingxiang
鸢尾素被认为可以反映氧化应激。本研究旨在证明血浆鸢尾素水平是否与血流动力学功能障碍相关，并预测特发性肺动脉高压（IPAH）患者的临床结果。本研究前瞻性招募了 68 名成年 IPAH 患者。通过 ELISA 方法测量入组的 IPAH 患者的血浆鸢尾素水平。根据不同血浆鸢尾素水平比较基线临床特征、血流动力学和临床结果。根据鸢尾素水平中位数将IPAH患者分为高鸢尾素组（鸢尾素≥7.3μg/ml）和低鸢尾素组（鸢尾素<7.3μg/ml）。高鸢尾素组的血浆总胆固醇水平（P = 0.027）和低密度脂蛋白胆固醇（LDL-C）水平（P = 0.042）较高，并且与血浆鸢尾素水平呈正相关。低鸢尾素组IPAH患者的平均肺动脉压（mPAP，P = 0.047）、肺动脉收缩压（sPAP，P = 0.022）、右心室收缩压（sRVP，P = 0.007）、右心房平均压（mRAP，P = 0.043）和右心房收缩压（sRAP，P = 0.007）显着升高。 0.020）。 mRAP、sRAP 和右心房舒张压 (dRAP) 与血浆鸢尾素水平呈负相关。低鸢尾素组预测不良的血流动力学状态和较差的无事件生存率（P = 0.030，对数秩检验）。多变量分析表明，调整相关协变量后，血浆鸢尾素水平是 IPAH 患者预后的独立预测因子（HR 0.786；95% CI 0.584、0.957；P = 0.038）。血浆鸢尾素水平可作为 IPAH 患者血流动力学严重程度评估和临床结果评估的新型生物标志物。
Irisin has been considered to reflect oxidative stress. This study aimed to show whether plasma irisin levels are correlated with hemodynamic dysfunction and predict the clinical outcome of patients with idiopathic pulmonary arterial hypertension (IPAH). A total of 68 adult IPAH patients were prospectively recruited in the present study. Plasma irisin levels were measured by the ELISA method in enrolled IPAH patients. Baseline clinical characteristics, and hemodynamic and clinical outcome were compared according to different plasma irisin levels. IPAH patients were divided into high irisin group (irisin >= 7.3 mu g/ml) and low irisin group (irisin < 7.3 mu g/ml) according to median values of irisin levels. Total plasma cholesterol levels (P = 0.027) and low-density lipoprotein cholesterol (LDL-C) levels (P = 0.042) were higher in high irisin group and were positively correlated with plasma irisin levels. IPAH patients in low irisin group had a significantly higher mean pulmonary artery pressure (mPAP,P = 0.047), systolic pulmonary artery pressure (sPAP,P = 0.022), systolic right-ventricular pressure (sRVP,P = 0.007), mean right atrial pressure (mRAP,P = 0.043), and systolic right atrial pressure (sRAP,P = 0.020). mRAP, sRAP, and diastolic right atrial pressure (dRAP) were negatively correlated with plasma irisin levels. Low irisin group predicts adverse hemodynamic status and poor free of event survival rate (P = 0.030, log-rank test). Multivariate analysis indicates plasma irisin levels to be an independent predictor of prognosis in IPAH patients after adjusting for related covariates (HR 0.786; 95% CI 0.584, 0.957;P = 0.038). Plasma irisin levels may serve as a novel biomarker in IPAH patients for hemodynamic severity assessment and clinical outcome evaluation.