An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing
An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing
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DOI：
10.1177/08853282221110315
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发表时间：
2022-06
影响因子：
2.9
通讯作者：
Shuang Yang;Li-Ping Lan;Mingda Gong;Ke Yang;Xiaoming Li
中科院分区：
文献类型：
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作者：
Shuang Yang;Li-Ping Lan;Mingda Gong;Ke Yang;Xiaoming Li
有效的敷料对于伤口愈合至关重要。事实上，润湿性能是伤口敷料最重要的因素之一。伤口敷料的基本功能包括吸收多余的渗出物并通过控制水分蒸发来维持伤口的最佳湿度。在这里，我们设计了一种具有不对称润湿性表面的壳聚糖（CS）海绵和PCL纳米纤维膜复合敷料，作为生物医学应用的伤口愈合材料。复合敷料的疏水表面具有防水性，可以有效控制水蒸气透过率，而CS海绵的亲水表面具有良好的细胞相容性和吸水能力。 CS海绵中添加了胰岛素样生长因子2（IGF-2），对成纤维细胞的迁移和增殖表现出刺激作用。因此，所制备的CS海绵和PCL膜复合敷料具有优异的细胞相容性、蒸汽透过率、液体吸收性和不对称润湿性，表明其有潜力成为传统伤口敷料的替代品。
An effective dressing is essential for wound healing. In fact, the wettability performance is one of the most important factors of a wound dressing. The fundamental functions of a wound dressing involve the absorption of excess exudates and maintenance of optimal moisture at the wound by controlling water evaporation. Here, we designed a type of chitosan (CS) sponge and PCL nanofibrous membrane composite dressing with asymmetric wettability surfaces as wound healing materials for biomedical applications. The hydrophobic surfaces of the composite dressing were waterproof and could efficiently control the water vapor transmission rate, whereas the hydrophilic surface of the CS sponge had good cytocompatibility and water-absorbing capability. Insulin-like growth factor-2 (IGF-2) was added to the CS sponge, and exhibited a stimulatory effect on fibroblasts migration and proliferation. Therefore, the fabricated CS sponge and PCL membrane composite dressing had excellent cytocompatibility, vapor transmission rate, and liquid absorption and asymmetric wettability, suggesting its potential as a promising alternative to traditional wound dressing.