Talaromynoids A-I, Highly Oxygenated Meroterpenoids from the Marine-Derived Fungus Talaromyces purpureogenus SCSIO 41517 and Their Lipid Accumulation Inhibitory Activities
Talaromynoids A-I, Highly Oxygenated Meroterpenoids from the Marine-Derived Fungus Talaromyces purpureogenus SCSIO 41517 and Their Lipid Accumulation Inhibitory Activities
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DOI：
10.1021/acs.jnatprod.1c00681
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发表时间：
2021-10-01
影响因子：
5.1
通讯作者：
Qi, Shu-Hua
中科院分区：
文献类型：
--
作者：
Huang, Zhong-Hui;Liang, Xiao;Qi, Shu-Hua
从海洋源真菌Talaromyces purpureogenus SCSIO 41517中分离得到9个新的3,5-二甲基苯甲酸衍生的高氧衍生物talaromynoids A-I（1-9）。通过HRMS、NMR、单晶x射线衍射分析和电子圆二色性计算对其结构和绝对构型进行了表征。化合物1和7-9分别具有前所未有的5/7/6/5 /6/6、6/7/6/ 6/6/5、6/7/6/5、6/7/6/ 4和7/6/5/6/5多环体系。生物学上，化合物5对磷酸酶CDC25B表现出选择性抑制活性，IC50值为13 μ M.此外，化合物7-9和化合物12在3T3-L1脂肪细胞中表现出降低甘油三酯的活性，且呈剂量依赖性。
Nine new highly oxygenated 3,5-dimethylorsellinic acid-derived meroterpenoids, talaromynoids A-I (1-9), were isolated from the marine-derived fungus Talaromyces purpureogenus SCSIO 41517. Their structures including absolute configurations were elucidated by HRMS, NMR, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. Compounds 1 and 7-9 possessed unprecedented 5/7/6/5 /6/6, 6/7 /6/ 6/6/5, 6/7/6/5/6/5/4, and 7/6/5/6/5/4 polycyclic systems, respectively. Biologically, compound 5 showed selective inhibitory activity against phosphatase CDC25B with an IC50 value of 13 mu M. Moreover, 7-9 and 12 exhibited the activity of reducing triglyceride in 3T3-L1 adipocytes in a dosage-dependent manner.