Now You See It, Now You Don't—Closing in on Allostasis and Developmental Basis of Psychiatric Disorders

Now You See It, Now You Don't—Closing in on Allostasis and Developmental Basis of Psychiatric Disorders
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DOI:
10.1016/j.neuron.2010.02.010
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发表时间:
2010-02
期刊:
影响因子:
16.2
通讯作者:
B. Thompson;P. Levitt
B. Thompson;P. Levitt
中科院分区:
医学1区
文献类型:
--
作者:
B. Thompson;P. Levitt

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在Niwa等人的报告中,大脑发育早期的侮辱导致精神障碍的模式在影响多年后变得不那么神秘。精神分裂症风险基因DISC1的短暂降低可以改变前额叶皮质的神经化学、结构和功能。
The mode through which early insults in brain development result in the onset of psychiatric disorders years after impact become a little less mysterious with the report by Niwa et al. that a transient reduction of the schizophrenia risk geneDISC1can alter prefrontal cortex neurochemistry, architecture, and function.