DEVELOPMENT AND ANALYSIS OF A SMALL ANIMAL-MODEL SIMULATING HUMAN POST-BURN HYPERMETABOLIC RESPONSE
DEVELOPMENT AND ANALYSIS OF A SMALL ANIMAL-MODEL SIMULATING HUMAN POST-BURN HYPERMETABOLIC RESPONSE
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DOI：
10.1016/s0022-4804(78)80003-1
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发表时间：
1978-01-01
影响因子：
2.2
通讯作者：
MASON, AD
中科院分区：
文献类型：
--
作者：
HERNDON, DN;WILMORE, DW;MASON, AD
生长中的豚鼠和成年大鼠是人体对热损伤的代谢反应的良好模型，证明了烧伤面积和代谢率之间的剂量-反应关系，代谢率的升高与恢复期和高代谢阶段有关，可能会被外部加热改变但不会减轻。在观察到可靠的代谢率升高之前，必须产生50%的全身表面烧伤。成熟大鼠是3种动物模型中最好的，适合于评价热损伤高代谢反应的介质和调节剂。
Growing guinea pigs and mature rats are good models of the human metabolic response to thermal injury demonstrating a dose-response relationship between burn size and metabolic rate, an elevation in metabolic rate related to the stage of convalescence and hypermetabolism that may be altered but not abated by external heating. A 50% total body surface burn must be produced before reliable elevations in metabolic rate are observed. The mature rat is the best of the 3 animal models and is suitable for evaluation of the mediators and modulators of the hypermetabolic response to thermal injury.