The Nutrient Response Transcriptional Regulome of Arabidopsis
The Nutrient Response Transcriptional Regulome of Arabidopsis
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DOI：
10.1016/j.isci.2019.07.045
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发表时间：
2019-09-27
期刊：
影响因子：
5.8
通讯作者：
Ivanov, Rumen
中科院分区：
文献类型：
--
作者：
Brumbarova, Tzvetina;Ivanov, Rumen
植物对环境的变化作出积极的反应。营养可获得性的变化引发了大量的转录重新编程，我们的目标是系统地描述这些调整并确定负责的调节者。利用基于13个不同养分有效性异常的基因共表达分析，我们定义并分析了营养胁迫响应信号。我们确定了已知的调控因子，并可以预测先前与其他过程相关的转录调控因子在营养反应中的功能，从而将发育和环境相互作用联系起来。其中三个已知的转录调控因子，PIF4，HY5和NF-Y，以其在光信号中的作用而闻名，它们针对网络的很大一部分，并可能参与重塑全球拟南芥转录组，以响应营养供应的变化。我们提出了基因共表达和转录调控网络，即使是具有基本信息学技能的用户，也可以将其用作进一步探索调控事件和相关性的工具。
Plants respond actively to changes in their environment. Variations in nutrient availability elicit substantial transcriptional reprogramming, and we aimed to systematically describe these adjustments and identify the regulators responsible. Using gene coexpression analysis based on 13 different nutrient availability anomalies, we defined and analyzed nutrient stress response signatures. We identified known regulators and could predict functions in nutrient responses for transcriptional regulators previously associated with other processes, thus linking development and environmental interaction. Three of the identified transcriptional regulators, PIF4, HY5, and NF-Y, known from their role in light signaling, targeted a substantial part of the network and may participate in remodeling the global Arabidopsis transcriptome in response to variations of nutrient availability. We present gene coexpression and transcriptional regulation networks, which can be used as tools to further explore regulatory events and dependencies even by users with basic informatics skills.