Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus An Observational and Bidirectional Mendelian Randomization Study
Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus An Observational and Bidirectional Mendelian Randomization Study
复制标题
聚 (ADP-核糖) 聚合酶活性与 2 型糖尿病中的冠状动脉疾病观察性双向孟德尔随机研究
DOI：
10.1161/atvbaha.120.314712
复制
发表时间：
2020-10-01
影响因子：
8.7
通讯作者：
Wang, Xue-bin
中科院分区：
文献类型：
--
作者：
Cui, Ning-hua;Yang, Jun-mei;Wang, Xue-bin
目的：实验证据表明 PARP（聚[ADP-核糖]聚合酶）激活与糖尿病内皮功能障碍之间存在密切联系。在这里，我们测试了 2 型糖尿病 (T2DM) 患者循环白细胞中的 PARP 活性是否与冠状动脉疾病 (CAD) 相关。方法和结果：我们对 3149 名接受冠状动脉造影的中国 T2DM 患者进行了观察性和双向孟德尔随机化研究，分析了白细胞 PARP 活性、PARP1 和 PARP2 中的 16 个标签单核苷酸多态性以及 17 个 CAD 风险单核苷酸多态性。在 3149 名参与者中，对进一步接受经皮冠状动脉介入治疗的 1180 名参与者进行了为期 1 年的前瞻性随访，以追踪主要不良心脑血管事件。总体而言，较高的 PARP 活性与阻塞性 CAD 的比值比为 1.23，前瞻性地与经皮冠状动脉介入治疗后 1 年主要不良心脑血管事件的风险比为 1.34 相关（均 P
Objective: Experimental evidence suggests a close link between PARP (poly[ADP-ribose] polymerase) activation and diabetic endothelial dysfunction. Here, we tested whether PARP activity in circulating leukocytes was associated with coronary artery disease (CAD) among patients with type 2 diabetes mellitus (T2DM). Approach and Results: We performed observational and bidirectional Mendelian randomization studies of 3149 Chinese individuals with T2DM who underwent coronary angiography, with leukocyte PARP activity, 16 tag single-nucleotide polymorphisms inPARP1andPARP2, and 17 CAD risk single-nucleotide polymorphisms analyzed. Of 3149 participants, 1180 who further received percutaneous coronary intervention were prospectively followed for 1 year to track major adverse cardiovascular and cerebrovascular events. Overall, greater PARP activity was cross-sectionally associated with an odds ratio of 1.23 for obstructive CAD, and prospectively with a hazard ratio of 1.34 for 1-year major adverse cardiovascular and cerebrovascular events after percutaneous coronary intervention (bothP