Visible light irradiation promoted catalyst-free and solvent-free synthesis of pyrano[2,3-d]pyrimidine scaffolds at room temperature
Visible light irradiation promoted catalyst-free and solvent-free synthesis of pyrano[2,3-d]pyrimidine scaffolds at room temperature
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DOI：
10.1016/j.jscs.2020.06.006
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发表时间：
2020-08-01
影响因子：
5.6
通讯作者：
Mohamadpour, Farzaneh
中科院分区：
文献类型：
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作者：
Mohamadpour, Farzaneh
基于绿色化学原理，以可见光为绿色促进剂，采用Knoevenagel-Michael环化缩合反应，在室温下一锅合成了吡喃并[2，3-d]嘧啶类支架材料。完成反应所需的时间彻底缩短，同时以优异的产率获得产物。该绿色合成方法具有反应条件温和、无需柱色谱分离、无需催化剂、无溶剂、成本低、合成简单、一锅法、原子经济性高等优点。(C)2020作者由Elsevier B. V.代表沙特国王大学出版。
A catalyst-free and solvent-free synthetic route for convenient one-pot synthesizing pyrano[2,3-d] pyrimidine scaffolds through Knoevenagel-Michael cyclocondensation is reported using visible light irradiation as a green promoter at room temperature based on green chemistry principles. Completing the reactions takes thoroughly less time while obtaining the products in outstanding yields. This green method includes the application of non-hazardous reaction circumstances, direct work-up without column chromatographic separation, catalyst-free, solvent-free, cost effective, simple synthesis, one-pot procedure, and high atom-economy. (C) 2020 The Author. Published by Elsevier B.V. on behalf of King Saud University.