Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)
Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)
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DOI：
10.1016/j.scitotenv.2021.148643
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发表时间：
2021-06-28
影响因子：
9.8
通讯作者：
Katoh, Takahiko
中科院分区：
文献类型：
--
作者：
Nakaoka, Hiroko;Hisada, Aya;Katoh, Takahiko
近年来，与儿童神经发育障碍有关的问题越来越多，人们对环境化学品与儿童健康之间的关系越来越感兴趣。本研究的目的是利用日语翻译的年龄和阶段问卷，第三版（J-ASQ-3），检查母亲在产前暴露于挥发性有机化合物的职业或环境与儿童神经发育障碍风险之间是否存在关联。在解决问题（比值比（or）： 1.76, 95%可信区间（CI）： 0.99-3.12）和个人社交技能（or: 3.32, 95% CI: 1.46-7.55）方面，确定了与母体接触福尔马林或甲醛相关的12个月大儿童神经发育迟缓风险增加。目前尚不清楚这种趋势是否可逆，以及是否在12个月后观察到。需要进一步的研究和预防措施。(c) 2021提交人。这是一篇基于CC by-nc-nd许可（http://creativecommons.org/licenses/by-nc-nd/4.0/）的开放获取文章。
In recent years, there has been an increase in the number of problems associated with neurodevelopmental disorders in children, and there has been a growing interest in the relationship between environmental chemicals and children's health. The objective of this study was to examine whether an association exists between occupational or environmental prenatal maternal exposure to volatile organic compounds and the risk of neurodevelopmental disorders in children using Japanese translations of the Ages & Stages Questionnaires, Third Edition (J-ASQ-3). An increase in the risk of neurodevelopmental delay in 12-month-old children associated with maternal exposure to formalin or formaldehyde was identified in terms of problem-solving (odds ratio (OR): 1.76, 95% confidence interval (CI): 0.99-3.12) and personal-social skills (OR: 3.32, 95% CI: 1.46-7.55). It is not clear whether or not this tendency is reversible, and whether it is observed past 12 months of age. Further research and a preventive approach are needed. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).